Antiphospholipid Syndrome: Molecular Mechanisms and Novel Therapies

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Pathology".

Deadline for manuscript submissions: 31 August 2024 | Viewed by 299

Special Issue Editors

E-Mail Website
Guest Editor
Department of Experimental Medicine, “Sapienza” University of Rome, Rome, Italy
Interests: pathogenetic effect of antiphospholipid antibodies

E-Mail Website
Guest Editor
Department of Internal Medicine and Medical Specialities, “Sapienza” University of Rome, Rome, Italy
Interests: antiphospholipid syndrome

Special Issue Information

Dear Colleagues,

The Special Issue "Antiphospholipid Syndrome: New Diagnostic Markers, Molecular Mechanisms and Novel Therapies" will focus on advances in the characterization, diagnosis, molecular mechanisms, pathophysiology, and treatment of antiphospholipid syndrome (APS).

APS is a systemic autoimmune disease characterized by heterogeneous clinical manifestations mainly involving vascular thrombosis (affecting arterial, venous and microvascular circuits) and obstetric complications, found in association with the presence of circulating antiphospholipid antibodies (aPLs). If not diagnosed and adequately treated, APS could have a negative impact on the patient's quality of life. In this context, there is a need to explore new methods to refine the diagnosis process and assess disease risk stratification; thus, the identification of new tests for classical criteria aPL assays and non-criteria assays utilizing novel antigenic targets is of great interest. Moreover, new knowledge on the pathogenetic mechanisms of the disease could lead to new treatments that are able to improve the prognosis. Patients with APS show different aPL profiles, which may possibly explain the heterogeneity of the molecular mechanisms underlying the pathophysiology of APS. Nowadays, although it is well documented that these autoantibodies are not only disease markers but are also responsible for the induction of a procoagulant phenotype, the study of their precise contribution in the clinical manifestations of APS is constantly evolving. Various mechanisms have been proposed and others are emerging, contributing to the identification of new therapeutic targets for the management of APS disease using different and personalized therapeutic approaches for patients.

This Special Issue invites investigators to submit original articles or reviews and it may include both basic science and clinical research studies with a translational approach. The collection of papers featured in this Special Issue will support the management of APS in order to prevent inaccurate diagnoses and deleterious consequences for patients.

Dr. Antonella Capozzi
Dr. Simona Truglia
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • antiphospholipid syndrome
  • pathophysiology
  • management
  • treatment
  • antiphospholipid antibodies
  • molecular mechanisms
  • new biomarkers
  • diagnostic tests

Published Papers

This special issue is now open for submission.
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