Antiphospholipid Syndrome: Molecular Mechanisms and Novel Therapies
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Pathology".
Deadline for manuscript submissions: closed (20 January 2025) | Viewed by 1246
Special Issue Editors
Interests: pathogenetic effect of antiphospholipid antibodies
Special Issue Information
Dear Colleagues,
The Special Issue "Antiphospholipid Syndrome: New Diagnostic Markers, Molecular Mechanisms and Novel Therapies" will focus on advances in the characterization, diagnosis, molecular mechanisms, pathophysiology, and treatment of antiphospholipid syndrome (APS).
APS is a systemic autoimmune disease characterized by heterogeneous clinical manifestations mainly involving vascular thrombosis (affecting arterial, venous and microvascular circuits) and obstetric complications, found in association with the presence of circulating antiphospholipid antibodies (aPLs). If not diagnosed and adequately treated, APS could have a negative impact on the patient's quality of life. In this context, there is a need to explore new methods to refine the diagnosis process and assess disease risk stratification; thus, the identification of new tests for classical criteria aPL assays and non-criteria assays utilizing novel antigenic targets is of great interest. Moreover, new knowledge on the pathogenetic mechanisms of the disease could lead to new treatments that are able to improve the prognosis. Patients with APS show different aPL profiles, which may possibly explain the heterogeneity of the molecular mechanisms underlying the pathophysiology of APS. Nowadays, although it is well documented that these autoantibodies are not only disease markers but are also responsible for the induction of a procoagulant phenotype, the study of their precise contribution in the clinical manifestations of APS is constantly evolving. Various mechanisms have been proposed and others are emerging, contributing to the identification of new therapeutic targets for the management of APS disease using different and personalized therapeutic approaches for patients.
This Special Issue invites investigators to submit original articles or reviews and it may include both basic science and clinical research studies with a translational approach. The collection of papers featured in this Special Issue will support the management of APS in order to prevent inaccurate diagnoses and deleterious consequences for patients.
Dr. Antonella Capozzi
Dr. Simona Truglia
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- antiphospholipid syndrome
- pathophysiology
- management
- treatment
- antiphospholipid antibodies
- molecular mechanisms
- new biomarkers
- diagnostic tests
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue policies can be found here.
