TNF Family Members in Immunology, Virology and Cancer Therapy
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Immunology".
Deadline for manuscript submissions: closed (30 April 2022) | Viewed by 5432
Special Issue Editor
Interests: TNF receptor members; cross-talks between TNF receptors such as Fas and conventional chemotherapeutic drugs; molecular mechanisms underlying TNFR1 pleiotropic signaling; TRAIL signal transduction
Special Issue Information
Dear Colleagues,
TNF family members display pleiotropic functions. While most of them play a critical role in the immune system, like TNF, only a restricted number are naturally involved and necessary to remove unwanted cells infected by viruses or undergoing transformation. Amongst them TNF-Related Apoptosis-Inducing Ligand (TRAIL), whose binding to its cognate agonist receptors, namely TRAIL-R1/DR4 or TRAIL-R2/DR5 triggers cell death in virally-infected or cancer cells. TNF on the other hand is rather associated with pro-inflammatory functions and its ability to trigger cancer cell death is almost inexistent, unless the NF-kB pathway is shut down. Given that TRAIL administration in vivo is safe, contrary to TNF, TRAIL or its derivatives have has attracted major interest in oncology. Notwithstanding, because inhibition of TNF during anti-PD1 or -PDL1 antitumor therapies is emerging as a good opportunity to overcome resistance to cancer-immunotherapies, rational design and targeting of other members of the TNF family may provide as well novel opportunities in anti-cancer therapies or autoimmune diseases. Because recent evidence indicate that TRAIL receptors may in addition trigger non-apoptotic signaling, cell death upon unresolved ER stress regardless of TRAIL, promote stress-induced inflammation or regulate immune cell activity during viral infections, a better understanding of the TRAIL system or the discovery of novel molecules or means to restore TRAIL-induced apoptosis is likely to open novel therapeutic opportunities in oncology, immune and infectious.
This special issue aims at gathering the most recent findings on TNF/TNFR superfamily members in immunology, virology and cancer therapy. Original articles and reviews are welcome.
Dr. Olivier Micheau
Guest Editor
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Keywords
- TNFSF
- TNFRSF
- Cancer
- autoimmune diseases
- infectious diseases
- oncology
- immunology
- virology
- signaling
- therapy
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