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Cells
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Tumor-Vasculature Crosstalk during Tumor Progression: New Challenges & Perspectives
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Tumor-Vasculature Crosstalk during Tumor Progression: New Challenges & Perspectives

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Immunology".

Deadline for manuscript submissions: closed (15 July 2021) | Viewed by 3366

Special Issue Editors

Prof. María Yáñez-Mó

E-Mail Website
Guest Editor
1. Department of Molecular Biology, Universidad Autónoma de Madrid, Madrid, Spain
2. Centro de Biología Molecular Severo-Ochoa, IIS-IP, Madrid, Spain
Interests: tetraspanins; cell-cell communication; extracellular vesicles; inflammation; viral infection
Dr. Hector Peinado

E-Mail Website
Guest Editor
Spanish National Cancer Research Center (CNIO), Madrid, Spain
Interests: pre-metastatic niche; extracellular vesicles; metastasis; tumor microenvironment
Dr. Esther M. Lafuente

E-Mail Website
Guest Editor
Department of Immunology, Ophthalmology and ENT, Medical School, University Complutense of Madrid, Madrid, Spain
Interests: integrins; cell signaling; cell-cell communication; inflammation neutrophils; macrophages
Dr. Carlos Cabañas

E-Mail Website
Guest Editor
Cell-Cell Communication & Inflammation Unit, Centre for Molecular Biology “Severo Ochoa” (CSIC-UAM), 28049 Madrid, Spain
Interests: cell-cell communication; adhesion molecules; integrins; extracellular vesicles; tumor development and progression
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The tumor microenvironment (TME) strongly determines the different stages of cancer progression. It is composed by a complex mix of soluble factors and a cellular network including cancer cells and stromal cells, diverse immune cell populations, cancer associated fibroblasts (CAF) and tumor endothelial cells (TECs). The crosstalk between these populations contribute to the complexity of the TME. This communication occurs via direct cell-cell contact or indirectly by release of soluble factors and extracellular vesicles (EVs). These tumor-secreted factors influence endothelial cells and contribute to tumor neo-angiogenesis and metastasis shaping the vasculature surrounding tumors characterized by their atypical morphology, aberrant functionality and a deeply altered gene expression profile. Tumor-derived factors also contribute to the transformation of different stromal cells such as endothelial cells by promoting endothelial-mesenchymal transition (EndoMT). On the other hand, tumor vasculature can contribute to tumor progression and metastasis by modulating TME immunogenicity through immune cell recruitment and responses. Despite the fact that there has been enormous progress in the knowledge of the crosstalk between tumor and the surrounding vasculature, a better understanding of their structural and functional characteristics is essential in order to delineate new targeted therapies. The aim of this special issue is to provide a comprehensive overview of recent advances on the TME, specifically on the molecular mechanisms underlying the contribution of tumor vasculature to tumor progression, pre-metastatic niche formation and metastasis. Submission of articles in the following sub-themes, are particularly welcome:

  1. Characterization of the tumor microenvironment (TME) and the vasculature surrounding tumors along tumor progression.
  2. The role of soluble factors and extracellular vesicles (EVs) in the crosstalk between tumor, endothelial and immune cells.
  3. Improving therapeutic approaches targeting either the tumor cells or the surrounding vasculature along tumor dissemination and metastasis.
  4. Development of new technological approaches to study interactions, within the tumor microenvironment, of tumor cells with the surrounding vasculature.

We are looking forward to your contributions to this Special Issue.

Prof. María Yáñez-Mó
Dr. Hector Peinado
Dr. Esther M. Lafuente
Dr. Carlos Cabañas
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Tumor microenvironment
  • tumor vasculature
  • extracellular vesicles
  • pre metastatic niche
  • therapeutic strategies

Published Papers (1 paper)

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Research

16 pages, 6477 KiB  
Article
Engineering a Vascularized Hypoxic Tumor Model for Therapeutic Assessment
by Yuta Ando, Jeong Min Oh, Winfield Zhao, Madeleine Tran and Keyue Shen
Cells 2021, 10(9), 2201; https://doi.org/10.3390/cells10092201 - 26 Aug 2021
Cited by 13 | Viewed by 2901
Abstract
Solid tumors in advanced cancer often feature a structurally and functionally abnormal vasculature through tumor angiogenesis, which contributes to cancer progression, metastasis, and therapeutic resistances. Hypoxia is considered a major driver of angiogenesis in tumor microenvironments. However, there remains a lack of in [...] Read more.
Solid tumors in advanced cancer often feature a structurally and functionally abnormal vasculature through tumor angiogenesis, which contributes to cancer progression, metastasis, and therapeutic resistances. Hypoxia is considered a major driver of angiogenesis in tumor microenvironments. However, there remains a lack of in vitro models that recapitulate both the vasculature and hypoxia in the same model with physiological resemblance to the tumor microenvironment, while allowing for high-content spatiotemporal analyses for mechanistic studies and therapeutic evaluations. We have previously constructed a hypoxia microdevice that utilizes the metabolism of cancer cells to generate an oxygen gradient in the cancer cell layer as seen in solid tumor sections. Here, we have engineered a new composite microdevice-microfluidics platform that recapitulates a vascularized hypoxic tumor. Endothelial cells were seeded in a collagen channel formed by viscous fingering, to generate a rounded vascular lumen surrounding a hypoxic tumor section composed of cancer cells embedded in a 3-D hydrogel extracellular matrix. We demonstrated that the new device can be used with microscopy-based high-content analyses to track the vascular phenotypes, morphology, and sprouting into the hypoxic tumor section over a 7-day culture, as well as the response to different cancer/stromal cells. We further evaluated the integrity/leakiness of the vascular lumen in molecular delivery, and the potential of the platform to study the movement/trafficking of therapeutic immune cells. Therefore, our new platform can be used as a model for understanding tumor angiogenesis and therapeutic delivery/efficacy in vascularized hypoxic tumors. Full article
(This article belongs to the Special Issue Tumor-Vasculature Crosstalk during Tumor Progression: New Challenges & Perspectives)
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