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Cells
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Small RNA Regulators of Acetylcholine Signaling
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Small RNA Regulators of Acetylcholine Signaling

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cell Signaling".

Deadline for manuscript submissions: closed (10 January 2022) | Viewed by 3463

Special Issue Editors

Prof. Dr. Hermona Soreq

E-Mail Website
Guest Editor
The Alexander Silberman Institute of Life Sciences, Slesinger Chair of Molecular Neuroscience, The Edmond and Lily Safra Center for Brain Science, The Hebrew University of Jerusalem, The Edmond J. Safra Campus, Givat Ram, 91904 Jerusalem, Israel
Interests: cholinergic system; microRNAs; neurodegenerative diseases (Alzheimer’s, Parkinson’s); RNA-sequencing; sex-related transcriptome differences; antisense oligonucleotides
Dr. Kai Kummer

E-Mail Website
Guest Editor
Institute of Physiology, Medical University of Innsbruck, Schoepfstrasse 41/EG, A-6020 Innsbruck, Austria
Interests: neurophysiology; neuropathic pain; addiction; gene expression; microRNAs; bioinformatics

Special Issue Information

Dear Colleagues,

We cordially invite you to submit a manuscript for our special issue on “Small RNA Regulators of Acetylcholine Signaling”. In the last decade, small non-coding RNAs, including microRNAs, have been shown to be potent regulators of cell signaling. By gene silencing on the level of mRNA and/or protein they have the power to orchestrate both immune and neuronal processes. Only recently, transfer-RNA fragments (tRFs) have been found to accomplish similar tasks. Another strong modulator of a variety of physiological mechanisms, including cognition, anxiety and inflammation, is the neurotransmitter acetylcholine. Interestingly, a subgroup of microRNAs specifically targets a large number of cholinergic genes. These CholinomiRs can therefore exert a strong regulatory role on acetylcholine signaling. In this special issue, we want to unveil the contribution of CholinomiRs and other small non-coding RNAs to the modulation of different physiological processes. Therefore, we invite submissions of all types of unpublished research contributions, preferably original research articles and topical reviews, from various fields, including high-throughput screening in health and disease, bioinformatics and computational biology. 

Prof. Dr. Hermona Soreq
Dr. Kai Kummer
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Non-coding RNA
  • microRNA
  • cholinergic
  • cholinomiRs
  • RNA sequencing
  • gene regulation

Published Papers (1 paper)

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Research

21 pages, 3830 KiB  
Article
Distinct CholinomiR Blood Cell Signature as a Potential Modulator of the Cholinergic System in Women with Fibromyalgia Syndrome
by Christoph Erbacher, Shani Vaknine, Gilli Moshitzky, Sebastian Lobentanzer, Lina Eisenberg, Dimitar Evdokimov, Claudia Sommer, David S. Greenberg, Hermona Soreq and Nurcan Üçeyler
Cells 2022, 11(8), 1276; https://doi.org/10.3390/cells11081276 - 9 Apr 2022
Cited by 8 | Viewed by 2924
Abstract
Fibromyalgia syndrome (FMS) is a heterogeneous chronic pain syndrome characterized by musculoskeletal pain and other key co-morbidities including fatigue and a depressed mood. FMS involves altered functioning of the central and peripheral nervous system (CNS, PNS) and immune system, but the specific molecular [...] Read more.
Fibromyalgia syndrome (FMS) is a heterogeneous chronic pain syndrome characterized by musculoskeletal pain and other key co-morbidities including fatigue and a depressed mood. FMS involves altered functioning of the central and peripheral nervous system (CNS, PNS) and immune system, but the specific molecular pathophysiology remains unclear. Anti-cholinergic treatment is effective in FMS patient subgroups, and cholinergic signaling is a strong modulator of CNS and PNS immune processes. Therefore, we used whole blood small RNA-sequencing of female FMS patients and healthy controls to profile microRNA regulators of cholinergic transcripts (CholinomiRs). We compared microRNA profiles with those from Parkinson’s disease (PD) patients with pain as disease controls. We validated the sequencing results with quantitative real-time PCR (qRT-PCR) and identified cholinergic targets. Further, we measured serum cholinesterase activity in FMS patients and healthy controls. Small RNA-sequencing revealed FMS-specific changes in 19 CholinomiRs compared to healthy controls and PD patients. qRT-PCR validated miR-182-5p upregulation, distinguishing FMS patients from healthy controls. mRNA targets of CholinomiRs bone morphogenic protein receptor 2 and interleukin 6 signal transducer were downregulated. Serum acetylcholinesterase levels and cholinesterase activity in FMS patients were unchanged. Our findings identified an FMS-specific CholinomiR signature in whole blood, modulating immune-related gene expression. Full article
(This article belongs to the Special Issue Small RNA Regulators of Acetylcholine Signaling)
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