Skin and Soft-Tissue Infections: From Molecular Mechanisms to Therapeutic Opportunities
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Immunology".
Deadline for manuscript submissions: closed (31 October 2020) | Viewed by 5733
Special Issue Editor
Special Issue Information
Dear Colleagues,
Skin and soft tissue infections (SSTI) can range from uncomplicated superficial infections at epithelial surfaces to more complex, necrotising infections in underlying tissues. Clinically, they can be difficult to classify, diagnose, and treat, problems that are compounded by the emergence of new infective organisms (e.g., Candida auris), anti-microbial resistance (AMR), and the formation of biofilms. For researchers, there are several other issues: the interactions between host and pathogen are difficult to model in the laboratory, with differences in anatomy and the immune response making animal models sometimes poor predictors of human infections; simple cell line models are suitable only for acute infections; and human tissue models can be difficult to obtain in a sufficient quantity for experimental purposes. Diagnosis of the infective agents can be problematic if the infection is deep-seated or takes the form of a biofilm with very low metabolic activity.
In this Special Issue, we aim to provide an open-access forum to address these issues, in the form of original research articles and reviews about SSTI and infections on other epithelial surfaces. The Special Issue is aimed at researchers using a wide range of tissue infection models, which may include animal models, ex vivo tissues, and reconstructed or engineered tissues, using physical, biochemical, and immunological techniques to study host–pathogen interactions, the microbiome, the role of predisposing factors (e.g., diabetes), inflammation, new drugs, and infection management techniques and diagnostics. We hope to stimulate new collaborations, therapeutic avenues, and technologies to advance our field and to expand the range of treatments available to clinicians.
Prof. Peter Monk
Guest Editor
Manuscript Submission Information
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Keywords
- wounds
- biofilms
- antibiotics
- skin and soft-tissue infections
- inflammation
