Obesity Pathogenesis: Insights from Molecular and Cellular Biology
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Pathology".
Deadline for manuscript submissions: closed (31 October 2023) | Viewed by 281
Special Issue Editor
Interests: obesity; type 2 diabetes; adipose tissue; browning; angiogenesis; cell biology; animal physiology; hypertension; metabolism; insulin resistance; human physiology; nutrition; metabolic diseases
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The global prevalence of obesity, characterized as the excess accumulation of adipose tissues, has reached epidemic proportions. Obesity is a significant risk factor in th development of a variety of chronic diseases, working to induce type 2 diabetes, fatty liver, cardiovascular diseases, neurodegenerative disorders, osteoarthritis, sleep apnea, and certain types of cancer.
The pathophysiology of obesity has been widely investigated, and an increasing number of signal transduction pathways have been found to be involved in obesity, making it possible to fight obesity in a more efficient and precise manner. These transduction pathways are believed to arise through a complex interplay between genetic and epigenetic predisposition, environment, and nutrition. In this regard, microRNAs (miRNAs) have emerged as key regulators of epigenetics pathways. Numerous studies have exhibited that miRNAs control different aspects of metabolic diseases such as the development of organs, release of and sensitivity to hormones, and are involved in an innumerable cellular process regulation, including proliferation, differentiation, DNA repair, apoptosis, and metabolism. Moreover, the discovery of circulating miRNAs, easily detectable in plasma and other body fluids, has highlighted their potential for use as both endocrine signaling molecules and disease indicators, or as potential biomarkers for the diagnosis or prognosis of obesity and associated diseases. Thus, therapeutic strategies that target these micro molecules could have great potential to fight obesity and other associated problems.
Dr. Rajaa El Bekay
Guest Editor
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