Acute Liver Failure: Molecular Actors in Liver–Adipose Tissue Interplay
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Tissues and Organs".
Deadline for manuscript submissions: 20 November 2025 | Viewed by 63
Special Issue Editor
Interests: acute and chronic liver disease; liver regeneration molecular mechanism; role of gender in liver biology; role of the immune system in the pathophysiology of the liver; role of the metabolism in liver and adipose tissue biology deregulation; liver and cardiac fibrosis in animal models of obesity; P2X7R/NLRP3 inflammasome axis in type 2 diabetes and its vascular complications; molecular mechanism of fibrosis dis-homeostasis
Special Issue Information
Dear Colleagues,
Acute liver failure (ALF) represents a group of severe clinical syndromes in which the rapid deterioration of liver functions leads to jaundice, coagulopathy, and a high mortality rate. Current treatments include pharmacotherapy and artificial liver support, but their therapeutic efficacy is limited. The only valid treatment is liver transplantation, with its multiple limitations (i.e., donor shortage, immune rejection after transplantation, life-long immune-suppressants). Alternative molecular and clinical strategies are an unmet need for ALF. This condition has been extensively and deeply investigated over the years, attempting to clarify and identify the roles of several novel actors in the mechanism which leads to organ failure and, possibly, its mitigation. The emerging role of adipose tissue as an active endocrine organ is of prominent interest, both as an active inflammation regulator and a systemic buffer.
In this Special Issue of Cells, I invite you to contribute original research articles, reviews, or perspective manuscripts on all aspects related to “Acute Liver Failure: Molecular Actors in Liver–Adipose Tissue Interplay”, especially expert insights into mechanistic, functional, cellular, or biochemical aspects of this topic. Relevant topics include, but are not limited to, the following:
- Cytokine signaling;
- Chemokine function;
- In vitro and in vivo models;
- Immunology;
- Extracellular matrix;
- Inflammasome;
- NASH/NAFLD;
- Alcohol;
- Hepatitis;
- Microbiota;
- Translational medicine.
Dr. Marika Crescenzi
Guest Editor
Manuscript Submission Information
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Keywords
- inflammasome
- adipose tissue
- acute liver injury
- adipokines
- liver macrophages
- hepatic stellate cells
- liver sinusoidal endothelial cells
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