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Advances in Bone Biology and Diseases: Pathophysiology, Mechanisms, and Therapeutic...
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Advances in Bone Biology and Diseases: Pathophysiology, Mechanisms, and Therapeutic Innovations

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Pathology".

Deadline for manuscript submissions: closed (15 April 2025) | Viewed by 772

Special Issue Editor

Dr. Baohong Zhao

E-Mail Website
Guest Editor
Weill Cornell Medicine and Hospital for Special Surgery Research, New York, NY 10021, USA
Interests: osteoimmunology; osteoclasts; pathological bone metabolism; inflammation; skeletal stem/progenitor cells

Special Issue Information

Dear Colleagues,

Bone diseases, ranging from osteoporosis and osteoarthritis to more complex conditions like Paget’s disease and bone cancers, significantly impact the quality of life of patients and healthcare systems worldwide. While many of these diseases are influenced by genetic, metabolic, and environmental factors, inflammation has emerged as a key driver in their pathophysiology. Recent advances in the interdisciplinary field of osteoimmunology have highlighted the intricate interplay between the immune system and bone health, offering new insights into disease mechanisms and potential therapeutic strategies.

This Special Issue, "Advances in Bone Biology and Diseases: Pathophysiology, Mechanisms, and Therapeutic Innovations", seeks to bring together cutting-edge research on the cellular and molecular underpinnings of bone diseases, with a particular focus on inflammation-mediated pathways. We invite contributions that explore novel diagnostic tools, biomarkers, and therapeutic approaches aimed at mitigating the progression of bone diseases. Original research and review articles that shed light on the interaction between immune cells, cytokines, and bone-resorbing or bone-forming cells are highly encouraged.

Join us in this Special Issue as we push the frontiers of knowledge in bone biology and disease research, with the ultimate goal of translating findings into effective treatments that enhance patient care and outcomes.

Dr. Baohong Zhao
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bone diseases
  • osteoimmunology
  • inflammation
  • osteoporosis
  • osteoarthritis
  • Paget’s disease
  • bone cancer
  • bone resorption
  • bone formation
  • cytokines
  • immune cells
  • pathophysiology
  • biomarkers
  • therapeutic strategies
  • molecular mechanisms
  • bone metabolism
  • inflammation-mediated pathways
  • bone remodeling
  • diagnostic tools
  • cellular interactions

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Published Papers (1 paper)

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Research

13 pages, 2729 KiB  
Article
Influence of Unidirectional Vacuum Application on Bone Healing in Maxillofacial Surgery
by Tom Alexander Schröder, Athanasios Karasavvas, Maximilian Bauckloh, Matthias C. Schulz, Günter Lauer and Lysann Michaela Kroschwald
Cells 2025, 14(10), 751; https://doi.org/10.3390/cells14100751 - 21 May 2025
Viewed by 481
Abstract
Negative-pressure wound therapy (NPWT) using vacuum-assisted closure (VAC) is a well known tissue defect bridging method that applies a vacuum pump to sterile, open-cell foam dressings via suction tubes. Although it has mostly been described for soft tissue use, there are also a [...] Read more.
Negative-pressure wound therapy (NPWT) using vacuum-assisted closure (VAC) is a well known tissue defect bridging method that applies a vacuum pump to sterile, open-cell foam dressings via suction tubes. Although it has mostly been described for soft tissue use, there are also a few studies concerning its use on hard tissue. However, as oral and maxillofacial surgery has to deal with both soft and hard tissue, which lie next to each other in these regions, there is a particular need to assess the influence of negative pressure on bone. Therefore, the effects of different negative pressure levels (530 mbar and 725 mbar) and atmospheric pressure (1013 mbar) on bone tissue cultures and osteoblast cell cultures were investigated over periods of 1, 3, and 6 weeks. During the culture period, osteoblast growth and the tissue regeneration of bone defects were studied in vitro using tissue cultures that were histologically supplemented by cytological investigations and quantitative RNA expression studies. In the bone defect model, there was a faster defect reduction using NPWT; the effect was especially strong for 530 mbar. Compared to the control group, up to 30% more newly generated bone tissue was detected. This effect on the mineralization capacity was assessed by the mRNA expression of osteogenic marker genes, as well as the receptor activator of nuclear factor κB ligand (RANKL) and osteoprotegerin (OPG), two multifaceted cytokines that regulate bone metabolism. The influence of negative pressure consequently resulted in a decreased RANKL/OPG ratio in osteoblasts. Associated with the upregulation of marker genes to up to 400%, including Col1, BMP4, OCN, and RUNX2, the decrease in the RANKL/OPG ratio to 41% indicates the stimulation of osteogenesis. Since VAC has been shown to be a safe and effective method to close wounds in general, these data suggest that patients suffering from compound bone and soft tissue defects in the maxillofacial area may benefit from an adapted therapy approach accelerating both soft and hard tissue regeneration. Full article
(This article belongs to the Special Issue Advances in Bone Biology and Diseases: Pathophysiology, Mechanisms, and Therapeutic Innovations)
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