Application of Organ-on-Chip Models to Study Cell and Tissue Function

Dear Colleagues,

The past decade has witnessed the emergence of the Organ-on-Chip (OoC) technology. The combination of microfabrication, biomaterials and (stem) cell biology has led to remarkable progress in this interdisciplinary field. Using a number of different approaches, various OoC models for a wide range of organs/tissues have been developed. These systems offer unprecedented opportunities to study complex biological processes in vitro. The aim of this Special Issue is to provide insight into how OoC models are used to study cell and tissue function. Special attention will be given to studies that go beyond proof of concept applications and provide in-depth characterization of cellular function, cell–cell interactions and/or tissue dynamics. This could comprise, for instance, in-situ monitoring of energy metabolism or the characterization of sex differences. Studies can, but do not have to, include testing of pharmaceutical compounds and should be based on well-defined human or animal cells (cell lines, primary, or stem cell derived). The overall objective of this Special Issue is to demonstrate the potential of OoC for mechanistic research.

We are looking forward to your contributions to this Special Issue.

Prof. Peter Loskill
Dr. Madalena Cipriano
Guest Editors

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• organ-on-chip
• microphysiological systems
• in vitro biology
• tissue dynamics
• metabolism
• 3Rs