Microscopy in Structural Biology Research
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cell Methods".
Deadline for manuscript submissions: 1 July 2025 | Viewed by 125
Special Issue Editor
Special Issue Information
Dear Colleagues,
One of the most ubiquitous themes of biology is structure determining function. In this regard, microscopy techniques have produced a wealth of information about molecular, sub-cellular, and cellular architectures. This Special Issue focuses on current state-of-the-art microscopy used in structural biology research, including the following:
- Optical microscopy: This includes various modalities such as wide-field, confocal, Airyscan, STED (stimulated emission–depletion), super-resolution, CARS (coherent anti-Stokes Raman scattering), darkfield, near-field, fluorescence, and fluorescence resonance energy transfer (FRET) microscopy, to name a few.
- Electron microscopy: Both scanning and transmission instruments can determine the ultrastructure of biological samples by using single-particle reconstruction, 3D reconstruction using serial blockface imaging, and cryo-imaging.
- Atomic force microscopy: A non-radiative, scanning probe technique that is used to determine the topography of biological samples, including live cell samples, with nanoscale resolution. Additionally, the physical properties of biological samples can be determined, for example, the elastic modulus, adhesion, deformation, and energy dissipation.
Dr. Chandran R. Sabanayagam
Guest Editor
Manuscript Submission Information
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Keywords
- cryo-electron microscopy (Cryo-EM)
- super-resolution microscopy
- X-ray crystallography
- structural biology
- cellular architecture
- biomolecular interactions
- high-resolution structural analysis
- integrative structural biology
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