RNA Processing Dysregulation in Human Cancers: Exploring New Actionable Vulnerabilities for Next-Generation Precision Medicine
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cell Nuclei: Function, Transport and Receptors".
Deadline for manuscript submissions: closed (31 July 2023) | Viewed by 194
Special Issue Editor
Special Issue Information
Dear Colleagues,
The advent of next-generation sequencing technologies in the past decade has uncovered the extreme complexity of the gene expression programs in higher eukaryotes. In particular, alternative splicing and polyadenylation generate multiple transcript variants from virtually every gene. Since many transcript variants exhibit different regulatory or functional properties, these processes enormously expand the coding potential of eukaryotes. While this represents an evolutionary advantage, the extreme flexibility of RNA processing regulation exposes the cell to an increased risk of producing aberrant transcripts. Indeed, mounting evidence points to the dysregulation of RNA processing as a common and important hallmark of human cancers. Cancer cells generally express a larger repertoire of splice variants with respect to healthy cells, and some of these cancer-specific variants display oncogenic properties. At the same time, however, RNA processing dysregulation exposes cancer cells to increased vulnerability with respect to the inhibition of specific pathways and processes. This Special Issue aims to describe new findings in the field of RNA processing regulation that have direct or indirect relevance for human cancers.
Themes of interest for the Special Issue include:
- Impact of alternative splicing and polyadenylation on tumorigenesis;
- Splicing-targeting drugs;
- Splicing-targeting approaches to human cancers;
- Regulatory pathways that affect RNA processing regulation in human cancers;
- RNA processing regulation by oncogenes;
- RNA-based therapies;
- Immunotherapy.
Prof. Dr. Claudio Sette
Guest Editor
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Keywords
- alternative splicing
- alternative polyadenylation
- human cancers
- actionable vulnerabilities
- precision medicine
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