Molecular Mechanisms of Neuronal Regeneration
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cells of the Nervous System".
Deadline for manuscript submissions: closed (30 April 2021) | Viewed by 271
Special Issue Editor
Special Issue Information
Santigo Ramón and Cajal classically postulated the difficulty of neuronal regeneration in the adult CNS. Although this dogma is still approved in a large number of cases of clinical neurosurgical or neurological patients, the new experimental facts show a part of the principles of successful neuronal regeneration. The presence of adult neural stem cells, and the effective differentiation from them to the neuron, may potentially have a positive role to play in this. There are many ways to achieve this based on molecular signalling for axon regrowth after neural tissue damage.
Neuronal regeneration is essentially different from the regeneration of the cells in other organs than the brain. The regenerated neuron should be differentiated from the neural stem cells in the adult brain, but they must migrate to the appropriate position, outgrow the axon and the dendrites, and perform the appropriate synaptogenesis to the accurate targets. These steps must correspond to the molecular pathways for neuronal regeneration. In addition, neuronal regeneration is believed to occur in response to recovery from CNS damage. Namely, recovery from the neuronal immune response and inflammation may be considered for the signalling pathways of neuronal regeneration. Not only neuron-intrinsic molecules but also glial ones and extracellular matrix components are known to affect neuronal regeneration processes.
In this Special Issue, the invited manuscripts should be focused on the above aspects, and the newly elucidated molecular pathways should be described and critically discussed in each step of regeneration.
Dr. Michihiro Igarashi
Guest Editor
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Keywords
- axon regeneration
- neuronal migration
- neurogenesis
- phosphorylation
- extracellular matrix
- glia
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