Special Issue "Mitochondria, Metabolism and Cancer"
Deadline for manuscript submissions: 30 September 2020.
Interests: cancer; mitochondrial metabolism; metabolic reprogramming; hybrid metabolic status; transmitocondrial cybrids and fatty acid oxidation
Special Issues and Collections in MDPI journals
Though the presence of abnormal metabolic activities in cancer tissues is well-established, it remains unclear how the cellular oncogenic states lead to the unusual metabolism and how the cancer metabolism contributes to tumorigenesis. In the traditional view based on the Warburg effect, cancer cells largely depend on glycolysis to produce energy even in the presence of oxygen. However, recent developments in cancer metabolism have established that both glycolysis and oxidative phosphorylation (OXPHOS) can be active in several aggressive cancer cells. Importantly, more and more experimental evidence upholds the critical role that actively functional mitochondria play in tumorigenesis and drug resistance. It has also been proposed that the metabolic plasticity in tumor cells might play a crucial role in cancer stemness and metastasis. Cancer mitochondria can utilize different kinds of resources, such as glucose, glutamine, and fatty acids, to fuel the electron transport chain (ETC) for OXPHOS. Moreover, the involvement of mitochondria in cell death mechanisms makes them important targets for tumor therapy.
Dr. Benny Abraham Kaipparettu
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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- cancer metabolism
- transmitochondrial hybrids
- metabolic reprogramming
- mitochondria–nuclear crosstalk
- hybrid metabolic status
- reactive oxygen species
- electron transport chain
- metabolic inhibitors