Exploring Mitochondrial Dysfunction and Neuroinflammation in Neurodegeneration for New Therapeutic Advances
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: 31 October 2025 | Viewed by 27
Special Issue Editor
Special Issue Information
Dear Colleagues,
Neurodegenerative diseases, including glaucoma, Alzheimer's disease, Parkinson's disease, multiple sclerosis, and other forms of central nervous system (CNS) neurodegeneration, remain among the leading causes of irreversible disability and neurological impairment worldwide. Despite significant advancements in our understanding of the molecular mechanisms involved, effective therapies that target the underlying causes of neurodegeneration remain limited. Mitochondrial dysfunction and neuroinflammation have been increasingly recognized as key contributors to the progression of these diseases, yet no effective neuroprotective treatments have been introduced in recent years. Current therapies primarily focus on symptom management, with few advancements in neuroprotective drugs since their introduction decades ago.
This Special Issue, titled Exploring Mitochondrial Dysfunction and Neuroinflammation in Neurodegeneration for New Therapeutic Advances, invites original research articles and reviews that explore the molecular pathways linking mitochondrial dysfunction, neuroinflammation, and neurodegeneration in the CNS. We aim to shed light on how these mechanisms contribute to diseases like glaucoma, Alzheimer's, Parkinson's, ALS, multiple sclerosis, and other CNS neurodegenerative disorders. Studies at the cellular, organ, or in vivo levels, as well as translational research with clinical relevance, are encouraged. Through this Special Issue, we seek to inspire the development of novel therapies that could potentially slow or halt neurodegenerative processes, improving patient outcomes across a variety of CNS diseases.
Dr. Hanhan Liu
Guest Editor
Manuscript Submission Information
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- mitochondria
- neuroinflammation
- neurodegeneration
- neuroprotective therapy
- innate immunity
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