Special Issue "Role of Extracellular Vesicles in Inflammatory Diseases"

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Immunology".

Deadline for manuscript submissions: 30 November 2023 | Viewed by 895

Special Issue Editors

Dr. Lahiru Gangoda
E-Mail Website
Guest Editor
1. Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, East Melbourne, VIC, Australia
2. Opthalmology, Department of Surgery, University of Melbourne, Melbourne, VIC, Australia
Interests: cancer; inflammation; cell death; extracellular vesicles
Dr. Ishara Atukorala
E-Mail Website
Guest Editor
1. Department of Obstetrics and Gynaecology, University of Melbourne, Melbourne, VIC, Australia
2. Mercy Perinatal, Mercy Hospital for Women, Heidelberg, VIC, Australia
3. Northern Center for Health Education and Research, Epping, VIC, Australia
Interests: reproductive biology; extracellular vesicles; perinatal infections

Special Issue Information

Dear Colleagues,

Over the last two decades, significant progress has been made toward understanding the generation and biological role of cell-derived extracellular vesicles (EVs). EVs are membrane-bound structures that are generated by an evolutionarily conserved process. They are secreted by nearly all cell types and present in all body fluids. EVs are potentially vital contributors to inflammation, which carry autoantigens, danger signals, cytokines, lipid mediators and tissue-degrading enzymes.  Sufficient evidence now exists to indicate that inflammatory diseases could be treated by targeting EV release. Furthermore, EVs evidently have critical roles in the initiation, progression and regulation of inflammatory diseases. This Special Issue aims to address the functions of EVs during inflammation and their potential as biomarkers, drug delivery vehicles and targets in inflammatory disorders.

Dr. Lahiru Gangoda
Dr. Ishara Atukorala
Guest Editors

Manuscript Submission Information

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Keywords

  • extracellular vesicles (EVs)
  • inflammation
  • biomarkers
  • inflammatory diseases
  • cytokines

Published Papers (1 paper)

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Review

Review
Beyond Macromolecules: Extracellular Vesicles as Regulators of Inflammatory Diseases
Cells 2023, 12(15), 1963; https://doi.org/10.3390/cells12151963 - 29 Jul 2023
Viewed by 654
Abstract
Inflammation is the defense mechanism of the immune system against harmful stimuli such as pathogens, toxic compounds, damaged cells, radiation, etc., and is characterized by tissue redness, swelling, heat generation, pain, and loss of tissue functions. Inflammation is essential in the recruitment of [...] Read more.
Inflammation is the defense mechanism of the immune system against harmful stimuli such as pathogens, toxic compounds, damaged cells, radiation, etc., and is characterized by tissue redness, swelling, heat generation, pain, and loss of tissue functions. Inflammation is essential in the recruitment of immune cells at the site of infection, which not only aids in the elimination of the cause, but also initiates the healing process. However, prolonged inflammation often brings about several chronic inflammatory disorders; hence, a balance between the pro- and anti-inflammatory responses is essential in order to eliminate the cause while producing the least damage to the host. A growing body of evidence indicates that extracellular vesicles (EVs) play a major role in cell–cell communication via the transfer of bioactive molecules in the form of proteins, lipids, DNA, RNAs, miRNAs, etc., between the cells. The present review provides a brief classification of the EVs followed by a detailed description of how EVs contribute to the pathogenesis of various inflammation-associated diseases and their implications as a therapeutic measure. The latter part of the review also highlights how EVs act as a bridging entity in blood coagulation disorders and associated inflammation. The findings illustrated in the present review may open a new therapeutic window to target EV-associated inflammatory responses, thereby minimizing the negative outcomes. Full article
(This article belongs to the Special Issue Role of Extracellular Vesicles in Inflammatory Diseases)
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