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Cells
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Inflammation in Cardiovascular Diseases in the COVID-19 Era
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Inflammation in Cardiovascular Diseases in the COVID-19 Era

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cells of the Cardiovascular System".

Deadline for manuscript submissions: closed (30 September 2022) | Viewed by 3508

Special Issue Editor

Prof. Dr. Fabrizio Montecucco

E-Mail Website
Guest Editor
IRCCS Ospedale Policlinico San Martino Genoa—Italian Cardiovascular Network, 10 Largo Benzi, 16132 Genoa, Italy
Interests: inflammatory; atherosclerosis; cardiovascular diseases; diabetes; cancer; infections

Special Issue Information

Dear Colleagues,

During COVID-19 pandemic, cardiovascular diseases were investigated, diagnosed and treated in a different way than before. In particular, it has been observed that cardiovascular diseases were somehow delayed with potential detrimental burden for patients and health care system. Therefore, cardiovascular diseases that the most important cause of death might impact on patients in the next months and years. This issue will accept both research article and reviews focused on all potential relationship between COVID-19 and chronic and acute Cardiovascular Diseases. Starting from pathophysiology to cardiovascular primary and secondary prevention till Hospital reorganization strategies and new managements of patients.

Prof. Dr. Fabrizio Montecucco
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • COVID-19
  • acute myocardial infartion
  • acute ischemic stroke
  • cardiovascular diseases

Published Papers (1 paper)

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Research

16 pages, 3454 KiB  
Article
Morphological Alterations and Stress Protein Variations in Lung Biopsies Obtained from Autopsies of COVID-19 Subjects
by Rosario Barone, Antonella Marino Gammazza, Letizia Paladino, Alessandro Pitruzzella, Giulio Spinoso, Monica Salerno, Francesco Sessa, Cristoforo Pomara, Francesco Cappello and Francesca Rappa
Cells 2021, 10(11), 3136; https://doi.org/10.3390/cells10113136 - 12 Nov 2021
Cited by 7 | Viewed by 3064
Abstract
Molecular chaperones, many of which are heat shock proteins, play a role in cell stress response and regulate the immune system in various ways, such as in inflammatory/autoimmune reactions. It would be interesting to study the involvement of these molecules in the damage [...] Read more.
Molecular chaperones, many of which are heat shock proteins, play a role in cell stress response and regulate the immune system in various ways, such as in inflammatory/autoimmune reactions. It would be interesting to study the involvement of these molecules in the damage done to COVID-19-infected lungs. In our study, we performed a histological analysis and an immunomorphological evaluation on lung samples from subjects who succumbed to COVID-19 and subjects who died from other causes. We also assessed Hsp60 and Hsp90 distribution in lung samples to determine their location and post-translational modifications. We found histological alterations that could be considered pathognomonic for COVID-19-related lung disease. Hsp60 and Hsp90 immunopositivity was significantly higher in the COVID-19 group compared to the controls, and immunolocalization was in the plasma membrane of the endothelial cells in COVID-19 subjects. The colocalization ratios for Hsp60/3-nitrotyrosine and Hsp60/acetylate-lisine were significantly increased in the COVID-19 group compared to the control group, similar to the colocalization ratio for Hsp90/acetylate-lisine. The histological and immunohistochemical findings led us to hypothesize that Hsp60 and Hsp90 might have a role in the onset of the thromboembolic phenomena that lead to death in a limited number of subjects affected by COVID-19. Further studies on a larger number of samples obtained from autopsies would allow to confirm these data as well as discover new biomarkers useful in the battle against this disease. Full article
(This article belongs to the Special Issue Inflammation in Cardiovascular Diseases in the COVID-19 Era)
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