Hedgehog Signaling in Myelin Diseases and Inflammatory Disorders of the Nervous System—Second Edition
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: closed (31 October 2024) | Viewed by 1619
Special Issue Editor
Interests: oligodendrocytes; microglia; astrocytes; myelin disorders; neural stem cells; Hedgehog signaling; androgens
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Until the end of the 20th century, proteins belonging to the Hedgehog family were essentially considered as morphogens acting at a distance from the cells that synthesized them via the establishment of a concentration gradient and controlling cell identities in the developing spinal cord. However, in recent decades, Hedgehog signaling has been found to be endowed with a multitude of other roles.
The involvement of Hedgehog signaling in the generation of oligodendrocytes, its requirement for proper development of peripheral nerve sheaths, as well as its implication in the maintenance of the blood–brain and blood–nerve barriers have raised the possibility that targeting Hedgehog signaling may open therapeutic perspectives towards demyelinating and inflammatory nervous system disorders.
The present Special Issue should provide an overview of the state of the art, namely, regarding the mechanisms underlying the involvement of Hedgehog signaling in myelin production, the therapeutic potential of Hedgehog signaling modulators in the process of myelin maintenance or regeneration, the contribution of Hedgehog signals to design cell therapies for myelin diseases, Hedgehog-mediated control of the blood–brain and blood–nerve barriers, and the role of Hedgehog signaling in glial cells participating in neuroinflammation.
Dr. Elisabeth Traiffort
Guest Editor
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Keywords
- Hedgehog signaling
- myelination
- myelin repair
- neuroinflammation
- glial cells
- blood–brain barrier
- blood–nerve barrier
- hedgehog modulators
- cell therapy
- nerve injury
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