Advances in Muscle Stem Cells and Development

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cell and Gene Therapy".

Deadline for manuscript submissions: closed (15 December 2024) | Viewed by 3449

Special Issue Editor


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Guest Editor
Laboratory of Muscle Stem Cells and Gene Regulation, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), NIH, Bethesda, MD 20892, USA
Interests: muscle stem cells; epigenetics; development; multi-omics

Special Issue Information

Dear Colleagues,

Muscle stem cells (MuSCs) are the resident stem cells in skeletal muscle tissues. They derive from myogenic precursors during development and gradually settle in the adult muscle niche along the course of muscle growth and homeostasis. MuSCs stay quiescent under normal conditions, while they could be activated upon injury and stress to regenerate and repair the tissue. During regeneration, a subset of them also returns to quiescence to sustain the stem cell pool, a quintessential character of adult stem cells. MuSCs’ function relates to homeostasis and a lot of myopathies, including atrophy, muscular dystrophy, and aging. Not surprisingly, they hold great therapeutic value and potential. Although signaling pathways, metabolism, and epigenetic remodeling intrinsic to MuSCs were proved to be essential to the fate and functions of them, more recent studies suggested that other cell types in the muscle tissue, such as fibro/adipogenic progenitors (FAPs), endothelial cells, and macrophages, also send critical signals to regulate their function during regeneration. With advances in deep sequencing, more and more transcriptomics, epigenomics, and multi-omics data with single-cell resolution or with spatial context on MuSCs have come out in the last five years. This provides a larger blueprint to study and test MuSCs under different physiological conditions and aging. It has never been this exciting to gain knowledge on the field of muscle biology and to test new ways to treat muscle diseases. Therefore, in this Special Issue, we invite labs to submit their new discoveries and review recent advances and perspectives in the field of muscle stem cells to extend our knowledge on this subject.

Dr. Xuesong Feng
Guest Editor

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Keywords

  • muscle stem cells
  • development
  • myogenesis
  • regeneration
  • myopathies

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Published Papers (2 papers)

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21 pages, 10250 KiB  
Article
RyR1 Is Involved in the Control of Myogenesis
by Amandine Tourel, Robin Reynaud-Dulaurier, Julie Brocard, Julien Fauré, Isabelle Marty and Anne Petiot
Cells 2025, 14(3), 158; https://doi.org/10.3390/cells14030158 - 21 Jan 2025
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Abstract
The RyR1 calcium release channel is a key player in skeletal muscle excitation–contraction coupling. Mutations in the RYR1 gene are associated with congenital myopathies. Recently, a role of RyR1 in myotubes differentiation has been proposed and attributed to its calcium channel function, which [...] Read more.
The RyR1 calcium release channel is a key player in skeletal muscle excitation–contraction coupling. Mutations in the RYR1 gene are associated with congenital myopathies. Recently, a role of RyR1 in myotubes differentiation has been proposed and attributed to its calcium channel function, which nonetheless remains to be clearly demonstrated. In order to clarify RyR1 role in myogenesis, we have developed an in vitro model, the so-called RyR1-Rec myotubes, which are mouse primary myotubes with an inducible decrease in RyR1 protein amount and in RyR1-mediated calcium release. Using this model, we showed that the RyR1 protein decrease was responsible for an increase in both differentiation and fusion, from the RNA level to the morphological level, without affecting the myogenic factors MyoD and MyoG. Although an increase in mTOR pathway was observed in RyR1-Rec myotubes, it did not seem to be responsible for the role of RyR1 in myogenesis. Additionally, even if modulation of intracellular calcium level affected RyR1-Rec myotubes differentiation, we have shown that the role of RyR1 in myogenesis was independent of its calcium channel function. Therefore, our findings indicate that, besides its pivotal role as a calcium channel responsible for muscle contraction, RyR1 fulfills a calcium-independent inhibitor function of myogenesis. Full article
(This article belongs to the Special Issue Advances in Muscle Stem Cells and Development)
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Review

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15 pages, 1446 KiB  
Review
Mitochondrial Dynamics Drive Muscle Stem Cell Progression from Quiescence to Myogenic Differentiation
by Olivia Sommers, Rholls A. Tomsine and Mireille Khacho
Cells 2024, 13(21), 1773; https://doi.org/10.3390/cells13211773 - 26 Oct 2024
Cited by 1 | Viewed by 2157
Abstract
From quiescence to activation and myogenic differentiation, muscle stem cells (MuSCs) experience drastic alterations in their signaling activity and metabolism. Through balanced cycles of fission and fusion, mitochondria alter their morphology and metabolism, allowing them to affect their decisive role in modulating MuSC [...] Read more.
From quiescence to activation and myogenic differentiation, muscle stem cells (MuSCs) experience drastic alterations in their signaling activity and metabolism. Through balanced cycles of fission and fusion, mitochondria alter their morphology and metabolism, allowing them to affect their decisive role in modulating MuSC activity and fate decisions. This tightly regulated process contributes to MuSC regulation by mediating changes in redox signaling pathways, cell cycle progression, and cell fate decisions. In this review, we discuss the role of mitochondrial dynamics as an integral modulator of MuSC activity, fate, and maintenance. Understanding the influence of mitochondrial dynamics in MuSCs in health and disease will further the development of therapeutics that support MuSC integrity and thus may aid in restoring the regenerative capacity of skeletal muscle. Full article
(This article belongs to the Special Issue Advances in Muscle Stem Cells and Development)
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