Forkhead-Box (Fox)O Family Transcription Factors in Cancer
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cell Nuclei: Function, Transport and Receptors".
Deadline for manuscript submissions: closed (15 June 2024) | Viewed by 2885
Special Issue Editors
Interests: growth factor signaling in solid tumors and metastasis; growth factor/steroid hormone crosstalk in hormone-dependent tumors; growth factors signaling proteins as markers of breast cancer progression; role of forkhead-box transcription factor 3a (FoxO3a) in the tumorigenesis and progression of breast cancer; mechanisms of resistance to endocrine therapy in breast cancer; multifunctional mesoporous silica nanoparticles as innovative devices for targeted therapy
Interests: role of the androgen receptor in hormone-dependent tumor growth and progression; molecular mechanisms underlying the functional crosstalk between estrogens, androgens, and growth factors in breast cancer; regulation of aromatase enzyme activity in the male gonad and in breast cancer cell lines
Special Issue Information
Dear Colleagues,
As Guest Editors of the Journal Cells (IF 7,666), we have the privilege to invite you to contribute a review or original article to the Special Issue “Forkhead-box (Fox) O Family Transcription Factors in Cancer”.
Forkhead-box class O (FoxO) family members FoxO1a, FoxO3a, FoxO4, and FoxO6 are nuclear transcription factors that control diverse biological processes, affecting development, metabolism, stem cell maintenance, and longevity. They have also been increasingly recognized as tumor suppressors for their ability to regulate the expression of genes involved in cell proliferation, DNA repair, apoptosis, angiogenesis, cell migration, and metastasis. Thus, deregulation of FoxOs expression and function has been associated with cancer initiation, progression, and drug resistance. However, several other studies have shown that FoxOs might also promote tumor progression in certain circumstances.
Therefore, this SI is aimed at deepening the understanding on FoxOs regulation and functions in cancer as well as in normal tissues, in order to clarify their prognostic value in various subsets of tumors and, at the same time, pave the way to more effective treatment options, exploiting FoxOs as targetable factors in cancer therapy.
Dr. Catia Morelli
Prof. Marilena Lanzino
Guest Editors
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Keywords
- forkhead-box class O transcription factors
- cancer
- apoptosis
- tumor progression
- EMT
- gene transcription
- drug resistance
- endocrine therapy
- lnRNA
- PTMs
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