Exosomes and Extracellular Vesicles in Health and Disease
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Intracellular and Plasma Membranes".
Deadline for manuscript submissions: closed (15 July 2019) | Viewed by 2910
Special Issue Editor
Special Issue Information
Dear Colleagues,
Extracellular vesicles (EVs, including exosomes and other membrane-bound packets) are released by all cells under all conditions, ranging from homeostatic equilibrium to states of stress. The cargo contained within those EV packets varies according to the state of the cell and includes byproducts of cellular housekeeping activities as well as molecular signals to neighboring cells. These packets of information, whether transferred between prochlorococci in ocean colonies, or transferred between cells of multicellular organisms, relay cell–cell information and thereby help to coordinate system-wide responses to stressors or changing conditions. In states of disease, these EVs, depending on their origin, may adaptively ameliorate the disease state or may contribute to the pathogenesis of the disease. Furthermore, because they are released from intercellular spaces into the circulation, they are being investigated through ‘liquid biopsies’ for various diseases and biological conditions.
EV research is complicated by the small size of EVs and the lack of tools to study different populations of these nano-sized packages in detail. With the emergence of new tools and methods for EV research, these challenges are being overcome, and the heterogeneity of EVs, their cargo, and their function in health and disease are beginning to be understood. The purpose of this Special Issue is to examine EV heterogeneity, biogenesis, and specific attributes of EVs as they relate to the balance between tissue repair versus cell death, tumor growth versus tumor regression, immune activation versus immune suppression, proliferation versus senescence, system-based integrity versus degradation, and other conditions that relate to health and disease. In providing this overview, this Special Issue will delineate the current foundations and tools for the next steps toward determining the roles of EV in pathogenesis and therapeutic strategies for the treatment of a wide range of diseases.
Dr. Jennifer Clare Jones
Guest Editor
Manuscript Submission Information
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Keywords
- exosomes
- extracellular vesicles
- precision medicine
- systems biology
- cellular biology
