Special Issue "Exosomes and Extracellular Vesicles in Health and Disease"
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: closed (15 July 2019).
Interests: cancer; radiation; immunotherapy; extracellular vesicles; liquid biopsy; precision medicine
Extracellular vesicles (EVs, including exosomes and other membrane-bound packets) are released by all cells under all conditions, ranging from homeostatic equilibrium to states of stress. The cargo contained within those EV packets varies according to the state of the cell and includes byproducts of cellular housekeeping activities as well as molecular signals to neighboring cells. These packets of information, whether transferred between prochlorococci in ocean colonies, or transferred between cells of multicellular organisms, relay cell–cell information and thereby help to coordinate system-wide responses to stressors or changing conditions. In states of disease, these EVs, depending on their origin, may adaptively ameliorate the disease state or may contribute to the pathogenesis of the disease. Furthermore, because they are released from intercellular spaces into the circulation, they are being investigated through ‘liquid biopsies’ for various diseases and biological conditions.
EV research is complicated by the small size of EVs and the lack of tools to study different populations of these nano-sized packages in detail. With the emergence of new tools and methods for EV research, these challenges are being overcome, and the heterogeneity of EVs, their cargo, and their function in health and disease are beginning to be understood. The purpose of this Special Issue is to examine EV heterogeneity, biogenesis, and specific attributes of EVs as they relate to the balance between tissue repair versus cell death, tumor growth versus tumor regression, immune activation versus immune suppression, proliferation versus senescence, system-based integrity versus degradation, and other conditions that relate to health and disease. In providing this overview, this Special Issue will delineate the current foundations and tools for the next steps toward determining the roles of EV in pathogenesis and therapeutic strategies for the treatment of a wide range of diseases.
Dr. Jennifer Clare Jones
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- extracellular vesicles
- precision medicine
- systems biology
- cellular biology