Mechanisms of Protein Homeostasis in Aging and Diseases

Dear Colleagues,

It is widely accepted that the accumulation of toxic proteins trails a progressive decline in the mechanisms that regulate protein homeostasis, or proteostasis, during aging. However, despite significant efforts, progress in terms of novel or improved therapies to either boost proteostasis networks or promote the removal of proteotoxic oligomers/aggregates, as well as prevent or even significantly delay age-related pathologies, has been rather limited.

Therefore, we have reached the point where we need to revisit the knowledge produced during past decades, go back to the drawing board, and use innovative in vitro as well as in vivo approaches to study proteostasis.

We know that proteostasis involves a network of cellular mechanisms, including protein synthesis, folding, transport, and degradation, as well as a transcellular network involving intercellular and intertissue communication in response to stress.

In this Special Issue we want to focus on cell-autonomous versus cell-nonautonomous proteostasis mechanisms, intercellular signaling in the regulation of proteostasis, cooperation between mitotic and postmitotic cells in proteostasis maintenance, the use of organoids and other innovative models for the study of proteostasis, new bioengineering tools, including the use of stem cells and their secretome for the development of new therapies, and new drug screenings in addition to improved tools for early diagnostics in age-related diseases.

Dr. Paulo Pereira
Dr. João Vasco Ferreira
Guest Editors

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• aging
• proteostasis
• age-related diseases