Functions of Cytochrome C in Cell Life and Disease
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: closed (10 April 2023) | Viewed by 721
Special Issue Editors
Interests: catalytical mechanism of Cytochrome c oxidase; coupled electron-proton transfer in heme proteins; protein stability
Special Issue Information
Dear Colleagues,
Proteins represent a diverse group of biomacromolecules that perform a myriad of functions inside and outside cells. One of them is a small, water-soluble globular protein—cytochrome c. It has attracted the attention of the scientific community for a long time, and one of the reasons is its multifunctionality. Among the physiological functions it plays, the three most intensively studied are: (i) electron transfer in relation to its canonical function as electron shuffling between complex III and complex IV in mitochondrial respiration; (ii) programmed cell activator death, apoptosis; and (iii) peroxidase-like activity in relation to pre-apoptotic events. Such different roles of cytochrome c in cell life and death are fine-tuned by some post-translational modifications of the protein. It turns out that its structural flexibility and involvement of alternative conformations can be another key to getting the functions it performs. This would not be possible without its interactions with organelle membranes or other structures in cells, including lipids, such as cardiolipin.
This Special Issue invites original research and review articles to help elucidate the molecular mechanisms of the various functions of cytochrome c in cell life and disease prevention and development, as well as to provide a new insight into the complex interaction networks where cytochrome c is involved.
Dr. Daniel Jancura
Dr. Rastislav Varhac
Guest Editors
Manuscript Submission Information
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Keywords
- Cytochrome c
- mitochondria
- electron transfer
- apoptosis
- peroxidase activity
- cardiolipin
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