CRISPR-Tools in Epigenetic Research
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cell Methods".
Deadline for manuscript submissions: closed (15 July 2023) | Viewed by 3940
Special Issue Editor
2. German Research Center for Environmental Health, Epigenetic Engineering, Institute of Stem Cell Research, Helmholtz Zentrum, 82152 Planegg-Martinsried, Germany
Interests: epigenome editing; CRISPR, dCas9; neurogenesis; neural stem cells; epigenetics; transcriptional engineering
Special Issue Information
Dear Colleagues,
Epigenetic processes regulate all aspects of life; however, it remains elusive which of the many known chromatin features are directly responsible for such processes. The question of causality has fascinated researchers in the field of epigenetics since its very beginnings. Even now, despite mapping a large number of “epigenomes” in a myriad of cell types, animals and patients, the number of individual chromatin marks known to cause a significant transcriptional or cellular change remains very low. Fortunately, new scalable experimental strategies based on CRISPR allow for a simple and efficient manipulation of chromatin, and thus promise to become a powerful tool for research and therapy alike.
This Special Issue will examine these approaches, including methods for the targeted manipulation of individual chromatin marks (epigenome editing, epigenetic engineering); the conditional manipulation of global chromatin features; targeted gene expression changes (CRISPRa, CRISPRi, transcriptional engineering); the generation of artificial transcription factors, epigenetic and epigenomic screens; and technologies allowing for the multiplexing of effectors and/or targeting sites. This Special Issue will also cover the generation of reliable systems for quantitative readouts of cellular consequences and is open to studies that convincingly demonstrate that certain chromatin features do not affect gene expression alone.
Prof. Dr. Stefan Stricker
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- epigenome editing
- CRISPR
- dCas9
- functional epigenetics
- chromatin
- transcriptional engineering
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue policies can be found here.
