Cytochrome C—Alternative Functions, New Interactions and Technological Applications

Dear Colleagues,

Cytochrome c (Сс) is a single-electron carrier between complex bc1 and cytochrome oxidase in the electron transport chain (ETC), located in the intermembrane space of mitochondria (IMS).

In recent years, this small (only 104 amino acids) alkaline protein has received the intense attention of the scientific community due to many additional functions that it plays in the cell: cardiolipin peroxidation, apoptose signaling, apoptosome formation, radical scavenging, participation via Mia40-ALR(Erv) in folding of dithiol proteins in IMS, etc. This Special Issue welcomes studies shedding light on structural features, post-translational modifications (phosphorylation, methylation) or partial activities of the enzyme, allowing it to perform additional functions. Additionally, we will be glad to consider the papers devoted to the design based on cytochrome c of various biosensors, detectors, as well as constructions potentially applicable in bio-nanoelectronics. At the same time, we will be less interested in the articles dealing with the traditional function of cytochrome c as en electron carrier in ETC.

Dr. Tatiana V. Vygodina
Dr. Rita V. Chertkova
Guest Editors

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