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10.5
5.2
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Cells
Special Issues
Translational Aspects of Cell Signaling
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Translational Aspects of Cell Signaling

A special issue of Cells (ISSN 2073-4409).

Deadline for manuscript submissions: 15 April 2026 | Viewed by 876

Special Issue Editor

Prof. Dr. Marc D. Basson

E-Mail Website
Guest Editor
College of Medicine, Northeast Ohio Medical University, Rootstown, OH, USA
Interests: mucosal healing; cancer biology; surgery
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Our understanding of the intricacies of cell signaling has increased exponentially over the past decades, and we are increasingly coming to understand the complexities and interactions between different signals and how they are regulated, including proteins, various species of RNA, and other moieties. While the signaling itself is fascinating, it also offers the opportunity to identify new targets by which we can intervene and affect change in the physiology or pathophysiology of the organism. Whether developing new drugs to treat disease or identifying predictive markers of subsequent outcomes, or even intervening to promote health, such signaling targets represent the future of medicine. This Special Issue offers the opportunity to glimpse that future.

Prof. Dr. Marc D. Basson
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cell signaling
  • drug development
  • prognostic markers
  • bioinformatics
  • translational research

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Published Papers (1 paper)

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Review

30 pages, 3986 KB  
Review
Mathematical Modeling of Cell Death and Survival: Toward an Integrated Computational Framework for Multi-Decision Regulatory Dynamics
by Elena Kutumova, Ilya Akberdin, Inna Lavrik and Fedor Kolpakov
Cells 2025, 14(22), 1792; https://doi.org/10.3390/cells14221792 - 14 Nov 2025
Viewed by 686
Abstract
Mathematical modeling is essential for understanding the complex regulatory pathways governing cell death and survival, including apoptosis, necroptosis, pyroptosis, ferroptosis, autophagy, and immunogenic cell death (ICD)—a functional category comprising diverse morphological types capable of activating immune responses. The growing number of models describing [...] Read more.
Mathematical modeling is essential for understanding the complex regulatory pathways governing cell death and survival, including apoptosis, necroptosis, pyroptosis, ferroptosis, autophagy, and immunogenic cell death (ICD)—a functional category comprising diverse morphological types capable of activating immune responses. The growing number of models describing individual signaling pathways poses the challenge of integrating them into a cohesive framework. This review aims to identify common components across existing ordinary differential equation models that could serve as key nodes to merge distinct signaling modalities. Proposed models highlight Bcl-2, Bax, Ca2, and p53 as shared regulators linking autophagy and apoptosis. Necroptosis and apoptosis are interconnected via TNF signaling network and modulated by caspase-8, c-FLIP, and NFκB, with RIPK1 acting as a critical hub directing pathway choice. Pyroptosis and apoptosis are co-regulated by NFκB, tBid, and caspases, while ferroptosis is modeled exclusively as an independent process, separate from other forms of cell death. Furthermore, existing models indicate that ICD intersects with necroptosis during oncolytic virotherapy, with pyroptosis in SARS-CoV-2 infection, and with apoptosis in the context of chemotherapy. Although several models address crosstalk between pairs of cell fate decisions, creating comprehensive frameworks that encompass three or more death modes remains an open challenge. Full article
(This article belongs to the Special Issue Translational Aspects of Cell Signaling)
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