Molecular and Cellular Mechanisms of Insulin Secretion
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Metabolism".
Deadline for manuscript submissions: 20 June 2026 | Viewed by 25
Special Issue Editor
Special Issue Information
Dear Colleagues,
Insulin secretion is central to glucose homeostasis, and its dysregulation underlies all forms of diabetes. Rapid advances in molecular biology, super-resolution imaging, single-cell genomics, and functional studies have opened new opportunities to dissect how pancreatic islet cells sense nutrients, integrate metabolic and electrical signals, and coordinate hormone release. Despite this progress, many key aspects of stimulus–secretion coupling, granule dynamics, and intra-islet communication remain insufficiently understood.
To accelerate discovery in this field, we are pleased to announce this Special Issue, titled “Molecular and Cellular Mechanisms of Insulin Secretion.” We invite original research articles and comprehensive reviews that address the diverse processes governing insulin release at molecular, cellular, and system levels. Topics of interest include, but are not limited to, nutrient sensing and metabolic signaling, ion channels and calcium dynamics, secretory granule biogenesis and exocytosis, β-cell heterogeneity, intercellular communication within the islet, and the modulatory roles of non-β endocrine cells. Submissions exploring emerging technologies or identifying novel therapeutic targets are especially welcome.
We hope this Special Issue will serve as a platform to advance mechanistic understandings of insulin secretion and foster collaboration across the metabolic research community.
Dr. Haiqiang Dou
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- insulin secretion
- beta-cells
- pancreatic islets
- diabetes
- exocytosis
- Ca2+
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