Tau-Targeted Treatment of Alzheimer’s Disease
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Neuroscience".
Deadline for manuscript submissions: 31 July 2026 | Viewed by 3
Special Issue Editors
Interests: neurodegenerative diseases; tauopathies; Alzheimer’s disease
Interests: tau protein; drosophila model; proteomics
Special Issues, Collections and Topics in MDPI journals
Interests: tauopathies; Alzheimer’s disease; drosophila models
Interests: associative and non-associative learning and memory; models of neurological and psychiatric disorders
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The pathological aggregation of tau protein into neurofibrillary tangles is a defining feature of Alzheimer's disease, closely correlated with cognitive decline and neurodegeneration. Accordingly, there is a critical need to characterize the molecular mechanisms driving tau misfolding, hyperphosphorylation and propagation to gain deeper insights into disease onset and progression. This requires the development of relevant disease models and therapeutic strategies that effectively target tau pathology in vivo. While tau-targeted approaches to modify the course of Alzheimer’s disease hold significant promise, their effectiveness in experimental and clinical settings remains to be fully realized.
This Special Issue will examine the molecular pathogenesis of tauopathy; emerging tau-centric therapeutic strategies, including immunotherapies, small-molecule inhibitors and gene therapies; the development and characterization of cellular and animal models for mechanistic study and drug screening; mechanisms of tau propagation and trans-synaptic spread and the identification of molecular biomarkers in model systems for diagnosing, staging and monitoring pathological progression.
Prof. Dr. Amritpal Mudher
Dr. Katerina Papanikolopoulou
Dr. Lovesha Sivanantharajah
Prof. Dr. Efthimios M. C. Skoulakis
Guest Editors
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Keywords
- tau protein
- Alzheimer's disease
- therapeutic targeting
- tauopathy
- neurodegeneration
- disease models
- drug discovery
- protein aggregation
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