Hematologic Diseases: From Cellular and Molecular Mechanisms to Therapies
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: 30 April 2026 | Viewed by 116
Special Issue Editors
Interests: normal and abnormal hematopoiesis; DNA damage repair; aging; hematopoietic stem cell-bone marrow niche interaction
Special Issues, Collections and Topics in MDPI journals
Interests: leukemia; lymphoma; targeted therapy; molecular diagnostics; high throughput genomics; transcriptomics
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Background and Significance
Hematologic disorders, encompassing malignant (e.g., leukemias, lymphomas, plasma cell neoplasms) and non-malignant entities (e.g., hemoglobinopathies, marrow failure syndromes, coagulopathies), contribute substantially to global morbidity and mortality. Advances in genomics, single-cell technologies, proteomics, and systems biology have elucidated critical mechanisms, including somatic mutations, epigenetic alterations, transcriptional dysregulation, and niche-mediated signaling. These insights have refined our understanding of disease ontogeny and progression.
Nevertheless, clinical translation remains a major challenge. Malignant hematologic diseases often exhibit clonal heterogeneity, dynamic evolution, and therapeutic resistance. Non-malignant conditions frequently lack mechanistic clarity and effective treatment paradigms. The advent of targeted agents, immunotherapies, and gene- and cell-based strategies underscores the need for integrative, mechanistically driven research across the translational spectrum.
Scope and Objectives
This Special Issue aims to showcase advances in the molecular and cellular pathogenesis of hematologic diseases and their implications for diagnosis, prognosis, and therapy. We invite original research, reviews, and communications addressing the following:
- Clonal evolution and molecular pathogenesis;
- Epigenetic and transcriptional regulation;
- Drug resistance mechanisms;
- Targeted and immune-based therapies;
- Biomarker discovery;
- Gene editing, stem cell biology, and cell-based interventions.
Our goal is to promote mechanistic insights that inform therapeutic innovation and improve clinical outcomes.
Dr. Wei Du
Dr. Pier Paolo Piccaluga
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- hematologic diseases
- mechanisms
- therapies
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