Antibody Production for Biotherapeutics Discovery and Development
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: closed (30 September 2023) | Viewed by 4044
Special Issue Editors
Interests: antibody production; biotherapeutics discovery and development; antibody engineering; antibody quality characterization; antibody efficacy; antibody pharmacodynamics and pharmacokinetics; antibody toxicology
Special Issue Information
Dear Colleagues,
The genetic mechanism of somatic recombination occurs during B cell and T cell maturation and results in the diversity of antibodies and T cell receptors, allowing for broad recognition of antigens from nearly all pathogens. This ground-breaking discovery was awarded the Nobel Prize in Physiology or Medicine in 1987 (Tonegawa). Propelled along by these and other seminal findings (e.g., Chemical structure of antibodies by Edelman and Porter, 1972; Hybridoma techniques for monoclonal antibodies by Kohler and Milstein, 1984; Phage display for antibodies by Winter and Smith, 2018), recombinant antibodies have become a major class of biologics for disease treatments and have a therapeutic impact on cancers, autoimmune and inflammatory diseases, as well as infectious diseases.
The current Special Issue of Cells aims to collect papers with a focus on antibody production for drug discovery and development. We welcome submissions on antibody production with original research and review articles exploring, but not limited to, the following specific sub-topics: Display technologies for antibody generation (phage, yeast, mRNA…); hybridoma and single-cell technologies for antibody generation and discovery; computational and rational antibody engineering; transient expression technologies for antibody production; stable cell line development for antibody production; bioprocessing for antibody production; antibody purification; molecular assessment for antibody production; antibody epitope binning and binding affinity determination; analytical studies for antibody production; pharmacodynamic and pharmacokinetic studies for antibodies; in vitro and in vivo efficacy studies for antibodies; and toxicology studies for antibodies.
Dr. Xiaotian Zhong
Dr. Brandon J. DeKosky
Guest Editors
Manuscript Submission Information
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- antibody production
- biotherapeutics discovery and development
- antibody engineering
- antibody quality characterization
- antibody efficacy
- antibody pharmacodynamics and pharmacokinetics
- antibody toxicology
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