Tumor–Microbiota Crosstalk: Immune Modulation and Resistance to Cancer Therapies

Dear Colleagues,

The gut and tumor-associated microbiota have emerged as critical regulators of cancer development, progression, and therapeutic response. The microbiota can modulate immune responses through several mechanisms, including the production of metabolites such as short-chain fatty acids that shape T cell differentiation, the activation of pattern recognition receptors that trigger innate immune pathways, and the modulation of cytokine networks that influence both local and systemic inflammation. This Special Issue aims to explore the complex interplay among microbial communities, the immune system, and tumor biology, focusing on how these interactions influence chemo- and immunoresistance. Contributions that investigate how these microbial–immune interactions affect cancer progression, therapy resistance, and patient outcomes, as well as strategies for manipulating the microbiota to enhance treatment efficacy, are encouraged. By integrating insights from immunology, oncology, and microbiome research, this Special Issue seeks to highlight novel approaches to overcoming therapeutic resistance and advance microbiota-informed cancer treatment strategies.

Dr. Massimiliano Berretta
Guest Editor

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