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In Vitro and In Vivo Pharmacology for Glioma Drug Discovery

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Drug Development".

Deadline for manuscript submissions: 30 November 2026 | Viewed by 1101

Special Issue Editor


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Guest Editor
Department of Pharmacology, School of Medicine in Katowice, Medical University of Silesia, 49613 Katowice, Poland
Interests: glioma; complementary therapy in glioma; glioma metabolism; remodeling of glioma metabolism; immunotherapy in glioma
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Special Issue Information

Dear Colleagues, 

Gliomas are a diverse group of brain tumors originating from glial cells. The aggressive nature of glioma, high mortality, and number of complications are still a serious problem in neuro-oncology. Standard treatments of glioma include surgical resection, chemotherapy with temozolomide (TEMO), radiotherapy, and new therapeutic strategies that seemed to be promising neither prolonged patients’ lives, nor did they reduce cancer recurrence rates. Therefore, there is a great effort to propose new therapeutic lines or to design new drugs for glioma therapy. Preclinical cancer models are valuable tools in oncology studies, including glioma, to recapitulate tumor microenvironments and host immune responses.  

Therefore, we are pleased to invite you to the Special Issue “In Vitro and In Vivo Pharmacology for Glioma Drug Discovery’’. The aim and scope of the Special Issue is to search for new strategies and drugs using modern in vitro and in vivo systems. In this Special Issue, original research articles and reviews are welcome. 

Dr. Anna Bielecka-Wajdman
Guest Editor

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Keywords

  • pre-clinical modern in vitro /in vivo glioma models
  • complementary glioma therapy
  • immunotherapy in glioma
  • inhibition of glioma recurrence

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Published Papers (1 paper)

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14 pages, 888 KB  
Systematic Review
Expression and Functional Role of the P2X7 Receptor in Glioma Models and Tissues: A Systematic Review
by Maciej Baron, Piotr Lewandowski, Bartosz Bula, Kamil Liberka, Andrzej Skrzypiec, Marcin Fyrla, Maciej Czwakiel, Małgorzata Wachowicz and Romuald Wojnicz
Cancers 2025, 17(23), 3748; https://doi.org/10.3390/cancers17233748 - 24 Nov 2025
Viewed by 752
Abstract
Background: Gliomas are the most common primary tumours of the central nervous system. Despite a multimodal therapeutic approach combining surgery, radiotherapy, and temozolomide (TMZ), treatment remains highly challenging, and the prognosis is poor. One of the potential molecular targets that may improve [...] Read more.
Background: Gliomas are the most common primary tumours of the central nervous system. Despite a multimodal therapeutic approach combining surgery, radiotherapy, and temozolomide (TMZ), treatment remains highly challenging, and the prognosis is poor. One of the potential molecular targets that may improve therapeutic outcomes is the purinergic receptor P2X7 (P2X7R). Methods: The aim of this systematic review was to summarize current knowledge on the expression, functionality, and therapeutic relevance of P2X7R in gliomas. A comprehensive literature search was conducted in three databases (PubMed, Scopus, and Web of Science) up to 12 April 2025. Original in vitro and in vivo studies evaluating P2X7R in glioma models were included. Results: A total of 41 studies met the inclusion criteria and were analyzed. For each included study, the risk of bias was assessed using the OHAT Risk of Bias Tool. The review protocol was registered in PROSPERO. Although individual studies differed in methodology and outcomes, the majority reported that P2X7R modulation affected glioma cell behaviour, including proliferation, survival, migration, immune signalling, and response to treatment. Due to the heterogeneity of models and endpoints, a narrative synthesis was performed. Conclusions: Overall, current evidence suggests that P2X7R may represent a biologically relevant and pharmacologically actionable target in gliomas, although further high-quality studies are required to confirm its clinical potential. Full article
(This article belongs to the Special Issue In Vitro and In Vivo Pharmacology for Glioma Drug Discovery)
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