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Late Recurrence in Breast Cancer

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Tumor Microenvironment".

Deadline for manuscript submissions: closed (31 August 2023) | Viewed by 4976

Special Issue Editor


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Guest Editor
Breast and Endocrine Surgery, Kumamoto City Hospital, 4 Chome-1-60 Higashimashi, Higashi Ward, Kumamoto 862-8505, Japan
Interests: breast cancer; HER2; cancer biomarkers; tumors: cancers; post-translational modifications; ubiquitination; thyroid cancer; ubiquitin

Special Issue Information

Dear Colleagues,

The majority of breast cancer (BC) metastasis does not appear at the same time as the primary tumor, and the time to recurrence varies considerably. Late recurrence, which occurs five or more years after the initial primary diagnosis, indicates a long dormant period of undetectable metastases, which therefore presents a significant clinical challenge for BC. Roughly 20–40% of estrogen receptor (ER)-positive BC patients eventually develop distant metastasis, and half of them correspond to late recurrence. Accurate and reliable estimates of the risk of late recurrence would enable appropriate management.

We invite authors to submit their original or review work to the Special Issue entitled “Late Recurrence in Breast Cancer" as it relates to late recurrence in tumor biology with a focus on the following:

  • Recurrence dynamics;
  • Tumor dormancy;
  • Dormancy cancer cell reactivation;
  • Biomarkers for detecting breast cancer patients with late recurrence;
  • Cancer stem cells;
  • Genomic profiles;
  • Tumor microenvironment;
  • Novel targets in dormancy cancer cells.

I look forward to receiving your contributions.

Dr. Takashi Takeshita
Guest Editor

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • late recurrence
  • recurrence dynamics
  • tumor dormancy
  • dormancy cancer cell reactivation
  • cancer stem cells
  • genomic profiles
  • tumor microenvironment

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Published Papers (1 paper)

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Research

16 pages, 3026 KiB  
Article
NR2F1, a Tumor Dormancy Marker, Is Expressed Predominantly in Cancer-Associated Fibroblasts and Is Associated with Suppressed Breast Cancer Cell Proliferation
by Rongrong Wu, Arya Mariam Roy, Yoshihisa Tokumaru, Shipra Gandhi, Mariko Asaoka, Masanori Oshi, Li Yan, Takashi Ishikawa and Kazuaki Takabe
Cancers 2022, 14(12), 2962; https://doi.org/10.3390/cancers14122962 - 15 Jun 2022
Cited by 21 | Viewed by 4464
Abstract
Background: Tumor dormancy is a crucial mechanism responsible for the late recurrence of breast cancer. Thus, we investigated the clinical relevance of the expression of NR2F1, a known dormancy biomarker. Methods: A total of 6758 transcriptomes of bulk tumors from multiple breast [...] Read more.
Background: Tumor dormancy is a crucial mechanism responsible for the late recurrence of breast cancer. Thus, we investigated the clinical relevance of the expression of NR2F1, a known dormancy biomarker. Methods: A total of 6758 transcriptomes of bulk tumors from multiple breast cancer patient cohorts and two single-cell sequence cohorts were analyzed. Results: Breast cancer (BC) with high NR2F1 expression enriched TGFβ signaling, multiple metastases, and stem cell-related pathways. Cell proliferation-related gene sets were suppressed, and MKi67 expression was lower in high NR2F1 BC. In tumors with high Nottingham grade, NR2F1 expression was found to be lower. There was no consistent relationship between NR2F1 expression and metastasis or survival. Cancer mutation rates, immune responses, and immune cell infiltrations were lower in high NR2F1 tumors, whereas the infiltration of stromal cells including cancer-associated fibroblasts (CAFs) was higher. NR2F1 was predominantly expressed in CAFs, particularly inflammatory CAFs, rather than in cancer cells, consistently in the two single-cell sequence cohorts. Conclusions: NR2F1 expression in breast cancer is associated with tumor dormancy traits, and it is predominantly expressed in CAFs in the tumor microenvironment. Full article
(This article belongs to the Special Issue Late Recurrence in Breast Cancer)
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