Adhesion and Integrins

Dear Colleagues,

Cancer initiation, growth, progression and metastasis are all stages of the disease that involve changes in both cell-cell and cell-matrix adhesion.  Such changes occur not only the tumour cell compartment but also in the stromal compartment, with changes in the adhesive capacity of immune cells, tumour associated fibroblasts, endothelial cells and so on. It is increasing evident that blockade of such adhesion molecules may have therapeutic value. The special issue of Cancers on ‘Adhesion and Integrins’ will include original research articles and review articles on the influence of adhesion molecules in cancer development and how we can exploit such changes for therapeutic advance.

Prof. Kairbaan Hodivala-Dilke
Guest Editor