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Cancers
Special Issues
Epidemiology and Prevention of Gastric Cancer
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Epidemiology and Prevention of Gastric Cancer

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Epidemiology and Prevention".

Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 5017

Special Issue Editors

Prof. Dr. Paolo Boffetta

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Guest Editor
Department of Family, Population and Preventive Medicine, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, USA
Interests: occupational and environmental epidemiology; cancer prevention and control; epidemiologic methods
Special Issues, Collections and Topics in MDPI journals
Dr. Giulia Collatuzzo

E-Mail Website
Guest Editor
Department of Medical and Surgical Sciences, University of Bologna, 40126 Bologna, Italy
Interests: cancer epidemiology; gastric cancer; Helicobacter pylori; attributable fraction; cancer screening; cancer prevention; occupational epidemiology
Special Issues, Collections and Topics in MDPI journals
Dr. Nuno Lunet

E-Mail Website
Guest Editor
1. EPI Unit-Instituto de Saúde Pública, Universidade do Porto, Rua das Taipas, 135, 4050-600 Porto, Portugal
2. Laboratório para a Investigação Integrativa e Translacional em Saúde Populacional (ITR), Rua das Taipas, 135, 4050-600 Porto, Portugal
3. Departamento de Ciências da Saúde Pública e Forenses e Educação Médica, Faculdade de Medicina da Universidade do Porto, Alameda Professor Hernâni Monteiro, 4200-319 Porto, Portugal
Interests: cancer epidemiology; systematic review; meta-analysis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues, 

This Special Issue aims to provide new insight into gastric cancer epidemiology and prevention. The continuous update of the estimates of incidence and mortality from gastric cancer is fundamental to describing the temporal trends of this disease and predicting future changes in its burden. Asian and less developed countries register the highest gastric cancer rates, given the strict relationship between lifestyle and socioeconomic factors and this neoplasm. The investigation of the risk factors underlying the disease, also distinguishing its anatomical and histological subsites, represents one of the major objectives of improving gastric cancer control policies. While Helicobacter pylori (Hp) remains a major cause of gastric cancer, mainly related to the non-cardia type and to the mucosa-associated lymphoid tissue of the stomach, several other modifiable factors are accounted as known risk factors. Evidence on many dietary factors and infectious agents other than Hp is still inconsistent, and little is known about the genes underlying gastric cancer risk. Furthermore, gastric cancer is connoted by high socioeconomic disparities, which also impact the difficult management of its outcome, which is often characterized by poor survival.Despite being largely preventable, there is no standardized program for its prevention, while some screening interventions have been implemented in high-risk countries. The Maastricht VI guidelines, which have been recently published, are cautious in recommendations around Hp management. Further research effort is required to clarify important features of gastric cancer and its subtypes and to define the cost-effectiveness of different potential approaches for its prevention.

Macroareas:

  • Interactions between risk factors;
  • Disparities;
  • Genetics and GxE interactions;
  • Increasing cardia cancer;
  • Hp screening;
  • AF of GC attributable to different risk factors;
  • Hp strains;
  • Water source; 
  • Diet;
  • Alcohol; 
  • Microbiota;
  • Studies from Africa;
  • Primary prevention (diet supplementation, salt reduction);
  • Endoscopic screening;
  • Biomarkers.

Prof. Dr. Paolo Boffetta
Dr. Giulia Collatuzzo
Dr. Nuno Lunet
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • gastric cancer
  • epidemiology
  • risk factors
  • Helicobacter pylori
  • non-cardia gastric cancer
  • cardia gastric cancer
  • gastric MALT
  • socioeconomic status
  • disparities
  • interaction
  • prevention
  • screening
  • biomarkers

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Published Papers (2 papers)

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Research

16 pages, 2493 KiB  
Article
Implementing an On-Slide Molecular Classification of Gastric Cancer: A Tissue Microarray Study
by Simona Costache, Rebecca de Havilland, Sofia Diaz McLynn, Maria Sajin, Adelina Baltan, Sarah Wedden and Corrado D’Arrigo
Cancers 2024, 16(1), 55; https://doi.org/10.3390/cancers16010055 - 21 Dec 2023
Cited by 2 | Viewed by 1736
Abstract
Background and Objectives: Gastric cancer (GC) is one of the most commonly diagnosed cancers and the fourth cause of cancer death worldwide. Personalised treatment improves GC outcomes. A molecular classification is needed to choose the appropriate therapy. A classification that uses on-slide biomarkers [...] Read more.
Background and Objectives: Gastric cancer (GC) is one of the most commonly diagnosed cancers and the fourth cause of cancer death worldwide. Personalised treatment improves GC outcomes. A molecular classification is needed to choose the appropriate therapy. A classification that uses on-slide biomarkers and formalin-fixed and paraffin-embedded (FFPE) tissue is preferable to comprehensive genomic analysis. In 2016, Setia and colleagues proposed an on-slide classification; however, this is not in widespread use. We propose a modification of this classification that has six subgroups: GC associated with Epstein–Barr virus (GC EBV+), GC with mismatch-repair deficiency (GC dMMR), GC with epithelial–mesenchymal transformation (GC EMT), GC with chromosomal instability (GC CIN), CG that is genomically stable (GC GS) and GC not otherwise specified (GC NOS). This classification also has a provision for biomarkers for current or emerging targeted therapies (Her2, PD-L1 and Claudin18.2). Here, we assess the implementation and feasibility of this inclusive working classification. Materials and Methods: We constructed a tissue microarray library from a cohort of 79 resection cases from FFPE tissue archives. We used a restricted panel of on-slide markers (EBER, MMR, E-cadherin, beta-catenin and p53), defined their interpretation algorithms and assigned each case to a specific molecular subtype. Results: GC EBV(+) cases were 6%, GC dMMR cases were 20%, GC EMT cases were 14%, GC CIN cases were 23%, GC GS cases were 29%, and GC NOS cases were 8%. Conclusions: This working classification uses markers that are widely available in histopathology and are easy to interpret. A diagnostic subgroup is obtained for 92% of the cases. The proportion of cases in each subgroup is in keeping with other published series. Widescale implementation appears feasible. A study using endoscopic biopsies is warranted. Full article
(This article belongs to the Special Issue Epidemiology and Prevention of Gastric Cancer)
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14 pages, 310 KiB  
Article
Sleep Duration and Stress Level in the Risk of Gastric Cancer: A Pooled Analysis of Case-Control Studies in the Stomach Cancer Pooling (StoP) Project
by Giulia Collatuzzo, Claudio Pelucchi, Eva Negri, Manolis Kogevinas, José María Huerta, Jesus Vioque, Manoli García de la Hera, Shoichiro Tsugane, Gerson Shigueaki Hamada, Akihisa Hidaka, Zuo-Feng Zhang, M. Constanza Camargo, Maria Paula Curado, Nuno Lunet, Carlo La Vecchia and Paolo Boffetta
Cancers 2023, 15(17), 4319; https://doi.org/10.3390/cancers15174319 - 29 Aug 2023
Cited by 6 | Viewed by 2722
Abstract
The association between sleep and stress and cancer is underinvestigated. We evaluated these factors in association with gastric cancer (GC). Five case-control studies from the Stomach Cancer Pooling (StoP) Project were included. We calculated the odds ratios (ORs) and the corresponding 95% confidence [...] Read more.
The association between sleep and stress and cancer is underinvestigated. We evaluated these factors in association with gastric cancer (GC). Five case-control studies from the Stomach Cancer Pooling (StoP) Project were included. We calculated the odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) for sleep duration and stress level in association with GC through multiple logistic regression models adjusted for several lifestyle factors. The analysis included 1293 cases and 4439 controls, 215 cardia and 919 noncardia GC, and 353 diffuse and 619 intestinal types. Sleep duration of ≥9 h was associated with GC (OR =1.57, 95% CI = 1.23–2.00) compared to 8 h. This was confirmed when stratifying by subsite (noncardia OR = 1.59, 95% CI = 1.22–2.08, and cardia OR = 1.63, 95% CI = 0.97–2.72) and histological type (diffuse OR = 1.65, 95% CI = 1.14–2.40 and intestinal OR = 1.24, 95% CI = 0.91–1.67). Stress was associated with GC (OR = 1.33, 95% CI = 1.18–1.50, continuous). This relationship was selectively related to noncardia GC (OR = 1.28, 95% 1.12–1.46, continuous). The risk of diffuse (OR = 1.32, 95% CI = 1.11–1.58) and intestinal type (OR = 1.23, 95% CI = 1.07–1.42) were higher when stress was reported. Results for the association between increasing level of stress and GC were heterogeneous by smoking and socioeconomic status (p for heterogeneity = 0.02 and <0.001, respectively). In conclusion, long sleep duration (≥9 h) was associated with GC and its subtype categories. Stress linearly increased the risk of GC and was related to noncardia GC. Full article
(This article belongs to the Special Issue Epidemiology and Prevention of Gastric Cancer)
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