The Role of Actin Binding Proteins in Cancer Progression
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Pathophysiology".
Deadline for manuscript submissions: 30 September 2025 | Viewed by 387
Special Issue Editor
Special Issue Information
Dear Colleagues,
Actin binding proteins (ABPs) play a crucial role in regulating the dynamics of the actin cytoskeleton, which is essential for cell shape, motility, and division. In cancer, alterations in ABP expression or function can profoundly impact tumor progression by modulating the architecture of the cytoskeleton, facilitating cell migration, invasion, and metastasis. ABPs influence processes such as actin polymerization, crosslinking, and severing, which are key to maintaining the structural integrity of cells and promoting dynamic changes required for tumor cells to invade surrounding tissues.
Additionally, ABPs are involved in signaling pathways that regulate cell cycle progression, apoptosis, and the epithelial-to-mesenchymal transition (EMT), all of which are critical to cancer initiation and metastasis. The dysregulation of ABPs, through mutations or altered expression levels, contributes to the aggressive behavior of cancer cells and their ability to evade therapeutic interventions. Understanding the intricate roles of ABPs in cancer progression offers promising avenues for developing targeted therapies aimed at restoring normal cytoskeletal dynamics and inhibiting metastasis.
Prof. Dr. Partha Roy
Guest Editor
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Keywords
- actin binding proteins
- cancer biology, cell migration
- angiogenesis, signaling pathways
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