Lymph Node Dissection in Colorectal Cancer

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Clinical Research of Cancer".

Deadline for manuscript submissions: 31 May 2024 | Viewed by 1836

Special Issue Editor


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Guest Editor
Department of Surgery, Osaka International Cancer Institute, 3-1, Otemae, Tyuou-ku, Osaka 541-8567, Japan
Interests: primary culture; tumor; cancer cells; gastroenterological tumor

Special Issue Information

Dear Colleagues,

Colorectal cancer (CRC) is the most common type of cancer and is one of the leading causes of cancer-related deaths. In recent years, CRC has been diagnosed at an early stage more frequently due to the recent advances in endoscopic techniques. Even for patients with early-stage CRC, clinicians must consider the type of treatment and the depth of submucosal invasion is considered the most important factor in determining a suitable treatment strategy. Surgical resection of CRC is the cornerstone of the treatment. However, colorectal surgery can be complex in some cases. The incidence of anastomotic leakage (AL) is high, and the postoperative mortality is therefore high due to AL. There is a general consensus that comorbidities play a crucial role in the outcome of the surgery. Recent reports have suggested that older patients with certain risks could be overtreated. Overtreatment results in the possibility of subsequent excess morbidity and mortality.

Patients also face a choice of treatment options. They must consider radical resection, oncological resection, and surveillance. Therefore, accurate risk stratification and predictive tools are highly valued to help them in this decision-making process. Here, we discuss the risk factors of LNM in CRC patients and the technology, strategy, and the future.

In this Special Issue, original research articles and reviews are welcome.

I look forward to receiving your contributions.

Dr. Norikatsu Miyoshi
Guest Editor

Manuscript Submission Information

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Keywords

  • colorectal cancer
  • CRC
  • lymph node dissection
  • diagnosis
  • therapy
  • endoscopic therapy
  • surgery
  • anastomotic leakage
  • AL
  • radical resection
  • oncological resection
  • surveillance
  • lymph node metastasis
  • LNM

Published Papers (1 paper)

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Research

11 pages, 477 KiB  
Article
Rectal Cancer: Are 12 Lymph Nodes the Limit?
by Paweł Mroczkowski, Łukasz Dziki, Tereza Vosikova, Ronny Otto, Anna Merecz-Sadowska, Radosław Zajdel, Karolina Zajdel, Hans Lippert and Olof Jannasch
Cancers 2023, 15(13), 3447; https://doi.org/10.3390/cancers15133447 - 30 Jun 2023
Cited by 1 | Viewed by 1498
Abstract
Lymph node dissection is a crucial element of oncologic rectal surgery. Many guidelines regard the removal of at least 12 lymph nodes as the quality criterion in rectal cancer. However, this recommendation remains controversial. This study examines the factors influencing the lymph node [...] Read more.
Lymph node dissection is a crucial element of oncologic rectal surgery. Many guidelines regard the removal of at least 12 lymph nodes as the quality criterion in rectal cancer. However, this recommendation remains controversial. This study examines the factors influencing the lymph node yield and the validity of the 12-lymph node limit. Patients with rectal cancer who underwent low anterior resection or abdominoperineal amputation between 2000 and 2010 were analyzed. In total, 20,966 patients from 381 hospitals were included. Less than 12 lymph nodes were found in 20.53% of men and 19.31% of women (p = 0.03). The number of lymph nodes yielded increased significantly from 2000, 2005 and 2010 within the quality assurance program for all procedures. The univariate analysis indicated a significant (p < 0.001) correlation between lymph node yield and gender, age, pre-therapeutic T-stage, risk factors and neoadjuvant therapy. The multivariate analyses found T3 stage, female sex, the presence of at least one risk factor and neoadjuvant therapy to have a significant influence on yield. The probability of finding a positive lymph node was proportional to the number of examined nodes with no plateau. There is a proportional relationship between the number of examined lymph nodes and the probability of finding an infiltrated node. Optimal surgical technique and pathological evaluation of the specimen cannot be replaced by a numeric cut-off value. Full article
(This article belongs to the Special Issue Lymph Node Dissection in Colorectal Cancer)
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