Surgical Treatment of Endocrine Cancer

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".

Deadline for manuscript submissions: closed (1 December 2024) | Viewed by 1474

Special Issue Editor


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Guest Editor
Endocrine, General and Digestive Surgery Department, Centre Hospitalier Universitaire de Limoges, Limoges, France
Interests: colorectal cancer; colorectal cancer initiating cells; mini-invasive surgery; endocrine surgery

Special Issue Information

Dear Colleagues,

Neuroendocrine tumors (NETs) are rare neoplasms. They arise from cells of the diffuse endocrine system, which are mainly dispersed throughout the body. While most NETs are sporadic, some are associated with genetic syndromes. Furthermore, some NETs are ‘functioning’ when there is clinical hypersecretion of metabolically active peptides, whereas others are ‘non-functioning’. Management requires a multidisciplinary discussion between the oncologist, radiologist, pathologist, and surgeon. Surgery is the main treatment in curative intent for neuroendocrine tumors (NETs).

In this Special Issue, we will discuss, through reviews/meta-analyses and original articles, which types of surgery may be proposed and in which way the preparation for surgery will take place. Follow-up of such management will also be analyzed.

Dr. Niki Christou
Guest Editor

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Keywords

  • neuroendocrine tumors
  • neuroendocrine carcinomas
  • surgical indications
  • surgical modalities
  • evaluation
  • preparation
  • follow-up
  • mini-invasive surgery
  • pathways

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Published Papers (1 paper)

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Review

17 pages, 2197 KiB  
Review
Surgical Management of Gastroenteropancreatic Neuroendocrine Tumors
by Lisa M. Kenney and Marybeth Hughes
Cancers 2025, 17(3), 377; https://doi.org/10.3390/cancers17030377 - 23 Jan 2025
Cited by 1 | Viewed by 1072
Abstract
Background/Objectives: Neuroendocrine tumors (NETs) are heterogeneous malignancies arising from enterochromaffin cells that can arise from the gastrointestinal (GI) tract and pancreas. Surgical management is the cornerstone of treatment, with the optimal approach tailored by tumor grade, size, location, and presence of metastasis. This [...] Read more.
Background/Objectives: Neuroendocrine tumors (NETs) are heterogeneous malignancies arising from enterochromaffin cells that can arise from the gastrointestinal (GI) tract and pancreas. Surgical management is the cornerstone of treatment, with the optimal approach tailored by tumor grade, size, location, and presence of metastasis. This review discusses the current strategies for the surgical management of NETs of the gastroenteropancreatic tract. Methods: A review of the available literature was conducted to evaluate surgical approaches to NETs. Consensus guidelines were incorporated to synthesize evidence-based recommendations. Results: For gastric NETs, surgical approach depends on Rindi Classification, WHO grade, and tumor size, with endoscopic approaches favored for smaller and low-grade lesions. Small bowel NETs can be multifocal and thus often require a surgical approach with careful evaluation of the entire intestine. Pancreatic NETs are categorized as functional or non-functional, with enucleation or formal resection strategies based on size, location, functional status, and risk of malignancy. Colorectal NETs are primarily treated with transanal localized or formal surgical resection, depending on lesion size and depth of invasion or presence of lymph node involvement. Appendiceal NETs are either treated with appendectomy or right hemicolectomy, depending on the size, location, and invasiveness of the lesions. For metastatic NETs, cytoreduction, liver transplantation, and targeted therapies offer symptom relief and possible survival benefits. Conclusions: Surgical resection provides curative potential for localized NETs and symptom control in metastatic cases. Future research is essential to refine guidelines for intermediate-risk lesions and multifocal tumors, ensuring optimal outcomes for patients with gastroenteropancreatic NETs. Full article
(This article belongs to the Special Issue Surgical Treatment of Endocrine Cancer)
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