T-Cells and Cancer: Recent Advances and Updates

Dear Colleagues,

T cells are circulating soldiers in our adaptive immune system, responding to exogenous and endogenous threats. In recognition of these signals, T cells differentiate into different subsets, which act in concert to ensure immune homeostasis and protect us from pathologies, such as cancer. Simply put, these subsets can be grouped into functional effector T cells (Teff) and suppressive regulatory T cells (Treg).

Unfortunately, the microenvironment in cancer renders T cells dysfunctional by suppressing Teff and promoting Treg. To overcome this barrier and elevate protective T cell-mediated anti-tumor immunity, ground-breaking immunotherapeutic strategies (IOs) have been pursued in recent years, including blocking immune checkpoints (ICBs) and generating super-T cells (e.g, CAR-T cells). Although IOs have induced great therapeutic benefits in some patients, challenges remain. To name a few, therapeutic resistance is common, mechanistic understanding is limited, and strategies of overcoming resistance are largely unknown.

In this Special Issue, we welcome cutting-edge research papers, constructive reviews, and insightful perspectives on T cells, the warriors that could eventually combat cancer.

Dr. Lewis Shi
Guest Editor

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• T cells
• CAR-T cells
• adaptive immune system
• immune homeostasis
• cancer microenvironment
• immune checkpoints
• T cell-mediated anti-tumor immunity
• therapeutic resistance