Heme Metabolism in Oncogenesis and Tumor Microenvironment: Mechanisms and Emerging Therapeutic Strategies
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Tumor Microenvironment".
Deadline for manuscript submissions: closed (31 October 2025) | Viewed by 1632
Special Issue Editors
2. Global Health, College of Public Health, University of South Florida, Tampa, FL 33612, USA
Interests: cancer metabolism and redox biology; tumor microenvironment; high-resolution multi-omics and spatial genomics; AI-driven data integration; oncogenic signaling and therapeutic targeting; translation of metabolic insights into precision oncology
Special Issues, Collections and Topics in MDPI journals
2. Department of Chemistry, College of Arts and Sciences, University of South Florida, Tampa, FL 33620, USA
Interests: biochemistry and enzymology of cellular metabolism; enzyme structure and function; cofactor and metal homeostasis; redox regulation and metabolic signaling; metabolic disorders and enzymopathies; biochemical pathways linking metabolism to cancer
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Heme metabolism plays a crucial role in cancer development and the tumor microenvironment. Aberrations in heme and porphyrin biosynthesis and regulation have been implicated in oncogenesis, influencing tumor progression, immune evasion, and redox homeostasis. Emerging evidence, including insights from recent CRISPR screens, highlights heme metabolism as a central pathway in various cancers. This Special Issue seeks contributions that explore mechanistic insights into the role of heme and porphyrins in cancer biology, as well as therapeutic strategies targeting heme biosynthesis and metabolism. We encourage the submission of research spanning molecular and cellular mechanisms to translational approaches, focusing on how altering heme pathways could present novel treatment options in cancer therapy.
Dr. Rays H.Y. Jiang
Prof. Dr. Gloria C. Ferreira
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- heme metabolism
- oncogenesis
- tumor microenvironment
- porphyrin biosynthesis
- redox homeostasis
- cancer metabolism
- heme biosynthesis pathways
- CRISPR screening
- iron metabolism
- therapeutic targeting of heme pathways
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