Management of Pancreatic Cancer: Prediction and Prognostic Factors

Dear Colleagues,

Pancreatic cancer is a leading cause of cancer-related deaths with an incidence that is forecast to increase in the near future. Regrettably, despite recent advances in its diagnostic and therapeutic management, prognosis remains poor. The aggressive behavior of the disease, the lack of cheap and user-friendly tools for early detection, and the high rates of postoperative morbidity and mortality together with the high radio-chemo resistances of the tumor are the leading factors responsible for the dismal prognosis. Over the last decade, a large number of different biomarkers have been identified; many have proved their efficacy, alone or in combination with Ca 19.9, in detecting PDAC; unfortunately, almost all of them failed to become reproducible in routine practice since they result from complex, expensive, and laborious technology. Nevertheless, in the field of cancer treatment, even the more recent strategies such as immunotherapy have failed due to the pancreatic cancer microenvironment.

You are kindly invited to share your knowledge, purposes, and recent advances in the management of pancreatic cancer in this Special Issue of Cancers.

Prof. Dr. Roberto Coppola
Prof. Dr. Damiano Caputo
Guest Editors

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