Molecular Mechanism in Wilms Tumor
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Molecular Cancer Biology".
Deadline for manuscript submissions: closed (15 January 2024) | Viewed by 251
Special Issue Editors
2. Pediatric Nephrology and Hypertension, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA
Interests: Wilms tumor; cancer stem cells; renal development; kidney organoids; pluripotent stem cells
Special Issue Information
Dear Colleagues,
In recent years, the pediatric cancer field has seen exciting developments in “biology-driven” approaches to drug discovery, patient risk stratification, and novel applications of experimental model systems; however, such advances in Wilms’ tumor have unfortunately lagged behind the progress seen in other childhood tumors. Even though the overall prognosis for most patients with Wilms’ tumor is relatively good, current treatment regimens consisting of cytotoxic chemotherapy, surgery, and radiation result in significant long-term morbidity for childhood cancer survivors, and a subset of patients with recurrent disease and/or unfavorable histology have much worse outcomes. Thus, there remains a critical need to advance the current understanding of molecular mechanisms in Wilms’ tumor biology in order to develop and employ the use of targeted therapies in the treatment of this rare pediatric kidney cancer.
We are pleased to invite you to contribute to this Special Issue of Cancers, which aims to highlight research addressing molecular mechanisms in the pathogenesis and treatment of Wilms’ tumor. Original research articles and reviews are welcome. Research areas may include (but are not limited to) basic, translational, and clinical studies directed at understanding mechanisms in the etiology, progression, and/or recurrence of Wilms’ tumor.
We look forward to receiving your contributions.
Dr. Naomi Pode-Shakked
Dr. Keri A. Drake
Guest Editors
Manuscript Submission Information
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Keywords
- Wilms tumor
- nephroblastoma
- pediatric cancer
- embryonal tumors
- cancer stem cells
- genetics
- epigenetics
- renal development
- therapy
- prognosis
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