Microbial-Based Cancer Therapies

Dear Colleagues,

Microbial-based cancer therapies (MBCTs) have been shown to augment anti-tumor immune responses and improve long-term clinical outcomes. Although reported successes extend across millennia and involve a spectrum of microbial species, the number of MBCTs that have been granted federal approval remain limited. Thus, there is great need for expanding awareness regarding MBCTs. Thus far, major mechanisms involve 1) debulking of the cancer via preferential tumor cell (versus normal cell) lysis by oncolytic pathogens and 2) conversion of the tumor microenvironment from “cold” (immune response-preventing) to “hot” (anti-tumor immunity-augmenting) by oncolytic and non-oncolytic pathogens, both active and inactivated. However, much more is to be gained from further studies and, thus, the need for a Special Issue covering the spectrum of MBCT-related discoveries from basic mechanisms to translational avenues, case studies, and clinical successes as an innovative means of improving and saving the lives of patients with cancer.

Dr. Andrew Zloza
Dr. Amanda L. Marzo
Guest Editors

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