Intensive Care and Cancers
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Epidemiology and Prevention".
Deadline for manuscript submissions: closed (30 November 2023) | Viewed by 2746
Special Issue Editor
Special Issue Information
Dear Colleagues,
Cancer patients are at high risk of developing life-threatening organ failures, the understanding of which is very important from a scientific and medical point of view, to provide short- and long-term curative solutions. These organ failures may be due to the malignancy itself, which may compress surrounding organs, or may also result from cancer-induced autoimmunity, cancer-related coagulopathy and blood disorders, or from metabolic disturbances, such as paraneoplastic hypo-natremia, hypercalcemia, or tumor lysis syndrome. Besides, cancer patients are immunocompromised, due to the underlying malignancy itself, and/or as a result of the immunosuppressive effect of numerous anti-tumor therapies, post-chemotherapy aplasia being only one example. These immune impairments increase the risk of bacterial sepsis and opportunistic infections, both of which can be life-threatening. All of these serious complications may require intensive care, especially since a large number of them are reversible when treated in time. Moreover, recent data from the literature suggest a major improvement in both short-term and long-term prognosis for cancer patients admitted to intensive care for an acute complication. Thus, this special issue offers a series of original articles and reviews aimed at better understanding the mechanisms leading to cancer-related immune dysfunctions autoimmunity or immunosuppression, coagulation disorders and metabolic disturbances, which are origin of these life-threatening organ failures requiring admission to intensive care. We also propose an update on existing knowledge on the outcome of cancer patients admitted to intensive care, and on acute management strategies while making the link with scientific advances. This translational research approach paves the way to strengthening cooperation between oncologists, intensivists, and researchers, a key point for refining the overall care of patients treated for malignant diseases and their inherent acute complications.
Dr. Raphaël Clere-Jehl
Guest Editor
Manuscript Submission Information
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Keywords
- neoplasms
- immunocompromised host
- critical care
- sepsis
- septic shock
- respiratory distress syndrome
- respiration artificial
- acute kidney injury
- renal replacement therapy
- opportunistic infections
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