Crosstalk Between Extracellular Matrix (ECM) and Intracellular Metabolism in Cancer

Dear Colleagues, 

Altered interactions between cancer cells and their surrounding extracellular matrix (ECM) drive many aspects of tumor progression, including proliferation, survival, migration, and invasion. Tumor progression is also hallmarked by alterations in intracellular metabolism, from localized mechanisms for energy sensing and generation to the global re-wiring of catabolic circuits. Each of these alterations promotes tumor cell plasticity and enhances the adaptive fitness required for efficient metastasis. However, the mechanisms through which matrix adhesion regulates metabolic plasticity and, conversely, through which altered intracellular metabolism influences adhesion dynamics are far from fully understood. However, significant recent work has revealed that these extrinsic and intrinsic factors intersect in unexpected, fascinating, and fundamentally important ways.

This Special Issue will review several aspects of the complex interplay between the extracellular matrix and intracellular metabolism. A deeper understanding of these regulatory axes will provide important insight into a fundamental facet of tumor cell biology and may also reveal novel pathways for therapeutic intervention.

Dr. Alan K. Howe
Guest Editor

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• extracellular matrix
• adhesion
• cell migration
• metabolism
• Warburg
• glycolysis
• ROS
• mitochondria
• AMPK