Current Trends in Epigenetics of Brain Tumors: Basic and Translational Research
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Pathophysiology".
Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 225
Special Issue Editors
Interests: pediatric brain tumors; noncoding RNA; epigenetics, genomics; translational biology
Special Issue Information
Brain tumors, classified as abnormal growths of cells in the brain and spinal cord, are one of the most complex and poorly understood forms of cancer. Over 100 different types of brain tumors, including non-malignant and malignant types, have been identified to date. They present with wide-ranging symptoms and have diverse prognoses, and therapeutic interventions are generally life-altering. Malignant brain tumors are particularly associated with poor prognosis and a very low survival rate. With the constant rise in cases of brain tumors worldwide, understanding the mechanisms of tumor formation and progression, therapy resistance, and immune-modulation, particularly in mostly immune-privileged brains, is imperative. Although genetic alterations in driver genes for some tumors have been identified, the driver mechanisms for the rest are still under investigation. Pediatric and adult brain tumors are particularly diverse, owing to the lower mutational burden in pediatric patients. Epigenetic regulation of gene expression has recently emerged as an important mechanism for tumor formation and carcinogenesis. Genetic alterations and environmental factors greatly influence the dynamics of cancer-associated epigenetic modifications that can, in turn, influence carcinogenesis. Recent advances in sequencing technology have enabled the simultaneous detection of genetic and epigenetic alterations within a single sequencing. This has enabled large-scale multi-omics studies aimed at diagnostic and basic research applications. Basic and translational research is needed to understand the factors influencing epigenetic modifications, landscapes of epigenetic changes in brain tumors, and clinical applications of these findings.
Dear Colleagues,
We are pleased to invite researchers in the field of epigenetics and brain tumors to contribute their original research, novel methods, and research articles to this Special Issue of Cancers titled “Current Trends in Epigenetics of brain tumors: Basic and translational research.” We invite experts in the field to contribute review articles summarizing the latest advances, current trends, and future perspectives in the field of epigenetics and brain tumors to this Special Issue. This Special Issue aims to publish high-quality original research and review articles advancing the field of epigenetics in brain tumors.
In this Special Issue, original research articles and reviews are welcome.
Research areas may include (but are not limited to) the following:
- Basic research in DNA and RNA epigenetics of brain tumors;
- Epigenetic role of noncoding RNA in brain tumors;
- Translational research in DNA and RNA epigenetics of brain tumors;
- Novel methods and resources related to DNA and RNA epigenetics of brain tumors;
- Computational biology research related to DNA and RNA epigenetics of brain tumors.
We look forward to receiving your contributions.
Dr. Ranjan Perera
Dr. Kandarp Joshi
Guest Editors
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Keywords
- brain tumors
- DNA methylation
- histone modifications
- microRNA and long noncoding RNA
- RNA modifications
- diagnostics
- translational research
- computational biology
- genomics
- long read sequencing
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