Surgery or Radiotherapy for Primary and Oligometastatic Lung Cancer
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".
Deadline for manuscript submissions: closed (31 May 2024) | Viewed by 313
Special Issue Editor
Special Issue Information
Dear Colleagues,
This Special Issue will focus on the management of lung cancer through different perspectives. In the past, the treatment decision was often easy: surgery for early lung cancer, radio-chemotherapy for locally advanced disease and a systemic treatment for metastatic disease. The progress made in different disciplines has led to a more sophisticated approach questioning the role and position of surgery or radiotherapy for early lung cancer but also in case of more advanced tumors. Surgery has evolved to a less invasive procedure with the introduction of video-assisted thoracic surgery, leading to a rapid recovery procedure and lower toxicities. In the area of radiotherapy, the technique has evolved to more precise targeting of the tumors with the introduction of intensity-modulated radiotherapy (IMRT), stereotactic ablative radiotherapy (SBRT) and adaptive radiotherapy, stereotactic body radiotherapy and on- line imaging procedures.
Systemic treatment has seen major breakthroughs with the introduction of molecular targeted therapy (TKis) and immune-checkpoint inhibitor monoclonal antibodies (the anti PD-1/PD-L1 compounds). This has not only improved the response rate but has also achieved long-term survival. Experimental data have also demonstrated some synergistic effects with local radiation. Trials suggested a real benefit to adding a local modality to this systemic treatment, especially for oligo metastatic disease. Questions are numerous: surgery or radiotherapy, the type of surgery or radiotherapy, the patient selection and the optimal timing, and so on.
The type of radiotherapy and surgery are also now more often discussed for the management of early lung cancer. The population aging, facing the issue of co-morbidity; moreover, screening programs have allowed more very early lung tumors to be found. Should we still apply our old approach or should we adapt our treatments?
In this Special Issue, colleagues from different disciplines will present their point of view on those issues outlining the progress, new approaches, area of research and possibilities for the future.
Prof. Dr. Paul Jules van Houtte
Guest Editor
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