Genomic Landscape of Myelodysplastic Syndromes

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Pathophysiology".

Deadline for manuscript submissions: 31 December 2024 | Viewed by 46

Special Issue Editor


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Guest Editor
Hemato-Oncology, Hirslanden Bern, Bern, Switzerland
Interests: haematology

Special Issue Information

Dear Colleagues,

The genomic landscape of MDS is complex and heterogeneous, involving a multitude of genetic and epigenetic alterations that drive disease pathogenesis and progression. Understanding these molecular mechanisms is essential for improving risk stratification, developing targeted therapies, and ultimately improving outcomes for patients with MDS.

We encourage researchers to submit articles in this Special Issue dedicated to the diagnostic, prognostic, predictive implications  as well as minimial-residual diesease monitoring of genetic and epigenetic alterations in myelodysplastic syndromes. These may include following aspects:

  1. Cytogenetic Abnormalities: MDS is associated with recurrent qualititative and quantitative cytogenetic abnormalities. These abnormalities can be assessed by conventional or array-based cytogenetic analyses. Alterations by conventional cytogenetics are important prognostic markers and guide risk stratification as well as treatment decisions, whereas the clinical impact of abnormalities assesed by novel approaches remais less clear.
  2. Somatic Mutations: Numerous somatic mutations have been identified in MDS, affecting genes involved in RNA splicing (e.g., SF3B1, SRSF2), epigenetic regulation (e.g., DNMT3A, TET2), and signaling pathways (e.g., TP53, NRAS). They have been recently incorporeted in risk stratification and treatment decisions.
  3. Clonal Evolution: MDS is characterized by clonal heterogeneity and evolution. It remains unclear, how these should be monitored for clinical decision making.
  4. Epigenetic Alterations: Dysregulation of DNA methylation, histone modifications, and chromatin remodeling plays a crucial role in MDS pathogenesis. Aberrant DNA methylation patterns are associated with silencing of tumor suppressor genes and dysregulated gene expression. It remains unclear, how these should be measured in a stadardized and reproducible way,
  5. Clonal Hematopoiesis of Indeterminate Potential: CHIP is a precursor to MDS and AML, highlighting the importance of identifying individuals at risk for disease progression. It remains unclear, how these should be monitored for clinical decision making.
  6. Therapeutic Implications: Advances in genomic profiling have led to the development of targeted therapies and personalized treatment approaches in MDS. Targeting specific mutations, such as IDH1/2 or SF3B1, shows promising efficacy in subsets of patients.

We look forward to receiving your contributions to further elucidate the genomic landscape of MDS and ultimately offer the potential for better outcomes for patients with this complex disorder.

Prof. Dr. Nicolas Bonadies
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • myelodysplastic syndrome
  • hematology
  • myelomonocytic leukemia
  • myeloproliferative neoplasms
  • genomics

Published Papers

This special issue is now open for submission.
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