Research on New Drugs and Drug Targets in Melanoma

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Drug Development".

Deadline for manuscript submissions: 20 August 2025 | Viewed by 835

Special Issue Editors


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Guest Editor
Department of Occupational Medicine, Medical University of Lublin, ul. Jaczewskiego 8b, 20-090 Lublin, Poland
Interests: melanoma; in vitro tests; isobolographic analysis; natural substances; pharmacodynamic interactions

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Guest Editor
Institut de Recherche Saint Louis (IRSL), Université de Paris, F-75010 Paris, France
Interests: melanoma; signal transduction; targeted therapies; drug resistance; MAPK; PI3K; cAMP
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Special Issue Information

Dear Colleagues,

The incidence of melanoma is steadily increasing worldwide. Malignant melanomas are dangerous skin cancers, and their treatment with various cytostatics often causes side effects; moreover, their prolonged use can lead to drug resistance. Surgical excision is the main method of treatment, and in the case of metastasis or resistance, other methods of treatment are available. Understanding the mechanisms and cellular pathways of melanoma allows for the development of more effective therapies, including immune checkpoint inhibitors, targeted therapies based on signaling pathways, intrafocal therapy (for unremovable melanomas) and local therapy (for single melanomas). The treatment of metastatic or drug-resistant melanoma still represents a significant therapeutic challenge. In recent years, new drugs have been introduced to treat melanoma, but scientists are still looking for new treatment options to improve therapeutic outcomes and increase patient survival.
The purpose of this Special Issue is to present new drugs or substances with potential against melanoma. Additionally, we are interested in drug targets and their mechanisms of action on many levels, including molecular and cellular.

Dr. Paula Wróblewska Łuczka
Dr. Nicolas Dumaz
Guest Editors

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Keywords

  • melanoma
  • new drugs
  • drug targets
  • mechanism of action
  • substances with anti-melanoma potential

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Published Papers (1 paper)

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Review

21 pages, 369 KiB  
Review
Novel Biological Strategies for Melanoma Therapy: A Focus on lncRNAs and Their Targeting
by Francesca Maria Orlandella, Rosaria Arcone, Neila Luciano, Giuliana Salvatore and Maria Letizia Motti
Cancers 2025, 17(8), 1273; https://doi.org/10.3390/cancers17081273 - 9 Apr 2025
Viewed by 401
Abstract
Increasing evidence revealed that restoring the correct expression of lncRNAs could have implications in the management of melanoma patients. In this context, here, we aim to dissect the main characteristics of lncRNAs altered in melanoma and their crosstalk with the signaling pathways involved [...] Read more.
Increasing evidence revealed that restoring the correct expression of lncRNAs could have implications in the management of melanoma patients. In this context, here, we aim to dissect the main characteristics of lncRNAs altered in melanoma and their crosstalk with the signaling pathways involved in the progression of this disease. We also highlight the role of nucleic acid-based techniques and natural compounds (i.e., phytochemicals) as a therapeutic tool to increase or silence their expression in cancer cells. Finally, we explore the advances in nanotechnologies as delivery systems to efficiently carry these chemicals into cancer cells, thus limiting their potential off-target effects. The analysis of the literature showed that HOTAIR, MALAT1, and H19 are the oncogenic lncRNAs most studied in melanoma, while MEG3 is an important tumor suppressor decreased in this cancer. The aberrant expression of these lncRNAs affects several hallmarks of cancer, e.g., proliferation, motility, and epithelial to mesenchymal transition, promoting the melanoma plasticity and drug resistance. In this frame, siRNA, antisense oligonucleotide, and CRISPR-Cas9 genome editing appear to be the most effective nucleic acid strategies to restore the physiologic expression of lncRNA, while curcumin, resveratrol, and quercetin are the main phytochemicals able to target and influence the expression of lncRNAs altered in cancer. Overall, this study provides a comprehensive overview regarding the role of lncRNAs in the phenotype plasticity of melanoma cells and their potential targeting using RNA-based therapy and natural products. Full article
(This article belongs to the Special Issue Research on New Drugs and Drug Targets in Melanoma)
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