Triggered Drug Delivery Strategies for Glioblastoma
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Drug Development".
Deadline for manuscript submissions: 31 July 2026 | Viewed by 143
Special Issue Editors
2. Coimbra Chemistry Centre, Institute of Molecular Sciences – IMS, University of Coimbra, Coimbra, Portugal
Interests: multimodal therapies; hybrid nanoparticles; blood-brain barrier modulation; tumor microenvironment targeting; glioblastoma therapy; translational nanotechnology
2. INEB—Instituto de Engenharia Biomédica, Universidade do Porto, Porto, Portugal
Interests: glioblastoma advanced in vitro models; tumor microenvironment interactions and signaling; therapeutic strategies for glioblastoma; mechanisms of antitumor drug action; target identification and cancer drug discovery
Special Issue Information
Dear Colleagues,
Glioblastoma presents extreme therapeutic challenges due to its infiltrative nature, dynamic tumor microenvironment, and limited drug accessibility across the blood-brain barrier. Stimuli-responsive drug delivery systems have emerged as powerful tools to address these limitations by enabling spatially and temporally controlled therapeutic release. This Special Issue focuses on advanced delivery platforms responsive to endogenous glioblastoma cues, such as redox gradients, enzymatic activity, acidic pH, and ionic dysregulation, as well as external triggers including ultrasound, photothermal and photodynamic activation, and magnetic fields. Emphasis is placed on systems integrating endogenous and exogenous stimuli to achieve synergistic, on-demand therapy with enhanced precision and reduced off-target toxicity. Original research and critical reviews covering material design, mechanistic insights, preclinical validation, and translational perspectives are encouraged.
Dr. Maria Mendes
Dr. Mariana Magalhães
Guest Editors
Manuscript Submission Information
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Keywords
- glioblastoma
- stimuli-responsive drug delivery
- tumor microenvironment
- smart nanocarriers
- endogenous-triggered release
- external stimulus-activated therapy
- combination therapy
- translational nanomedicine
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