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Surgical Treatment of Oral Squamous Cell Carcinoma

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Clinical Research of Cancer".

Deadline for manuscript submissions: closed (30 August 2025) | Viewed by 373

Special Issue Editors


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Guest Editor
1. Department of Otolaryngology—Head and Neck Surgery, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan
2. Molecular Medicine Research Center, Chang Gung University, Taoyuan, Taiwan
Interests: head and neck; oral cavity; nasopharynx; salivary gland; skull base

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Guest Editor
1. Department of Plastic and Reconstructive Surgery, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan
2. College of Medicine, Chang Gung University, Taoyuan, Taiwan
Interests: reconstruction; wound healing; plastic surgery

Special Issue Information

Dear Colleagues,

It is with great pleasure that I have accepted the invitation from Cancers to be the Editor of this Special Issue about the surgical treatment of oral squamous cell carcinoma. The surgical approach concerning resection and reconstruction of oral squamous cell carcinoma has undergone major changes in recent decades, and clinical practice has adjusted accordingly. The dramatic development of minimally invasive techniques and the advances in reconstruction investigations have led to personalized cancer medicine. The role of the surgeon, including head and neck surgeons and plastic surgeons, has therefore changed, and the interrelationships with oncologists and radiotherapists in common clinical practice are nowadays increasingly closer. Modern combination studies between chemotherapy, immunotherapy, and biological agents have dramatically redefined the prognosis of patients with head and neck malignancies. The surgical techniques required modifications by adapting to greater technical complexities related to tissue changes as the result of oncological treatments.

This Special Issue of Cancers therefore aims to reiterate this new trend of head and neck ablative and reconstructive surgery, reaffirming the concept that the treatment of oral squamous cell carcinoma according to radiological or biological manifestations still passes through their radical resection.

In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following:

  • Ablative surgery for oral squamous cell carcinoma according to radiological or biological characteristics (such as circulating markers or other clinicopathological features).
  • New reconstructive surgery or approaches for the head and neck region.
  • Induction chemotherapy or immunotherapy for oral squamous cell carcinoma.
  • The role of adjuvant treatments, especially proton therapy or other heavy particle therapy, for oral squamous cell carcinoma.

I look forward to receiving your contributions.

Prof. Dr. Kai-Ping Chang
Prof. Huang-Kai Kao
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • oral cavity
  • squamous cell carcinoma
  • OSCC
  • surgery
  • head and neck
  • resection
  • reconstruction
  • oncology

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Published Papers (1 paper)

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Research

10 pages, 544 KB  
Article
Prediction of Occult Cervical Lymph Node Metastasis in Bone-Invasive pT4a cN0 Oral Squamous Cell Carcinoma in Relation to Tumor Size: A Retrospective Observational Cohort Study
by Friedrich Mrosk, Victoria Vertic, Maximilian Richter, Erin Sprünken, Lukas Mödl, Jan Oliver Voss, Anna Sofroniou, Carsten Rendenbach, Max Heiland and Steffen Koerdt
Cancers 2025, 17(18), 3044; https://doi.org/10.3390/cancers17183044 - 18 Sep 2025
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Abstract
Objective: The T classification of oral squamous cell carcinoma (OSCC) is linear according to the tumor size, excluding T4a by its criteria of invasion into adjacent structures, such as cortical bone. This may lead to the upstaging of otherwise small tumors. The objective [...] Read more.
Objective: The T classification of oral squamous cell carcinoma (OSCC) is linear according to the tumor size, excluding T4a by its criteria of invasion into adjacent structures, such as cortical bone. This may lead to the upstaging of otherwise small tumors. The objective was to analyze patients with OSCC and negative nodal staging to assess the impact of T-staging with tumor size on the incidence of occult cervical lymph node metastasis (CLNM) and regional neck failure. Methods: This retrospective cohort study included patients with OSCC and clinically negative necks (cN0), treated surgically between 2010 and 2024. All T4a OSCC classified due to bone invasion were additionally reclassified into T1–T3 based on size and depth of invasion according to the current staging manual. The primary endpoint of this study was the association between OSCC stratified by T-stage and tumor size as well as the presence of occult CLNM. Results: A total of 642 patients were included, with an overall occult CLNM rate of 20.2%. Bone invasion in T1-sized tumors was significantly associated with occult CLNM (OR 6.38, 95% CI: 1.48–27.42), whereas no such association was observed in T2 or T3 tumors (OR 0.80, 95% CI: 0.37–1.73; and OR 0.77, 95% CI: 0.37–1.62, respectively). Additionally, in T1–T2 tumors, bone invasion did not correlate with worse survival outcomes. Conclusions: Bone invasion was not significantly associated with occult CLNM in T2-3 sized OSCC, suggesting that the prognostic relevance is size-dependent. These findings question the uniform upstaging to T4a and support a more differentiated approach, potentially enabling neck management de-escalation in selected early-stage cases. Full article
(This article belongs to the Special Issue Surgical Treatment of Oral Squamous Cell Carcinoma)
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